ChEMBL ligand: CHEMBL1243373
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] There should be some charts here, you may need to enable JavaScript!
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884] There should be some charts here, you may need to enable JavaScript!
prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL	Inhibition of human recombinant His-tagged DPP2 expressed in insect cells	B	4	pIC50	>100000	nM	IC50	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL	Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2013) 56: 3467-3477 [PMID:23594271]
ChEMBL	Inhibition of human recombinant His-tagged DPP4 expressed in insect cells	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
GtoPdb	-	-	4.7	pIC50	>20000	nM	IC50	J Med Chem (2010) 53: 6572-83 [PMID:20718420]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
ChEMBL	Inhibition of human recombinant His-tagged DPP9 expressed in insect cells	B	5.57	pIC50	2700	nM	IC50	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
GtoPdb	-	-	5.57	pIC50	2700	nM	IC50	J Med Chem (2010) 53: 6572-83 [PMID:20718420]
ChEMBL	Inhibition of human DPP9 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	B	6.38	pIC50	420	nM	IC50	J Med Chem (2013) 56: 3467-3477 [PMID:23594271]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
GtoPdb	-	-	5.43	pIC50	3700	nM	IC50	J Med Chem (2010) 53: 6572-83 [PMID:20718420]
ChEMBL	Inhibition of human recombinant His-tagged DPP8 expressed in insect cells	B	5.43	pIC50	3700	nM	IC50	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
ChEMBL	Inhibition of human DPP8 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2013) 56: 3467-3477 [PMID:23594271]
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL	Competitive inhibition of human recombinant FAP expressed in Hi5 insect cells by Lineweaver-Burke plot analysis	B	8.1	pKi	7.9	nM	Ki	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
GtoPdb	-	-	7.72	pIC50	19	nM	IC50	J Med Chem (2010) 53: 6572-83 [PMID:20718420]
ChEMBL	Inhibition of human recombinant FAP expressed in Hi5 insect cells	B	7.72	pIC50	19	nM	IC50	J Med Chem (2010) 53: 6572-6583 [PMID:20718420]
ChEMBL	Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2013) 56: 3467-3477 [PMID:23594271]
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
ChEMBL	Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2013) 56: 3467-3477 [PMID:23594271]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]