vidofludimus [Ligand Id: 9860] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL197194 (4SC-101, Imu-838, IMU-838, NSC-717824, SC-12267, SC12267, Vidofludimus) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879430] [UniProtKB: P0C870] | ||||||||
| ChEMBL | Inhibition of N-terminal His-tagged human JMJD7 (1 to 316 residues) expressed in Escherichia coli BL21 (DE3) luciferase based succinate-gloTM JmjC demethylase/hydroxylase assay | B | 5.15 | pIC50 | 7160 | nM | IC50 | Bioorg Med Chem Lett (2021) 45: 128139-128139 [PMID:34048880] |
| dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] | ||||||||
| ChEMBL | Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay | B | 6.87 | pIC50 | 134 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4854-4857 [PMID:16143532] |
| ChEMBL | Inhibitory activity against recombinant human DHODH | B | 6.87 | pIC50 | 134 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 267-270 [PMID:16246558] |
| GtoPdb | Determined in an indirect in vitro enzyme assay which measures the reduced co-substrate ubiquinone. | - | 7.32 | pIC50 | 48 | nM | IC50 | Am J Pathol (2010) 176: 2840-7 [PMID:20413687] |
| ChEMBL | Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular response upto 72 hrs by luciferase reporter gene assay | B | 5.55 | pEC50 | 2800 | nM | EC50 | Eur J Med Chem (2020) 186: 111855-111855 [PMID:31740051] |
| ChEMBL | Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular response upto 72 hrs by luciferase reporter gene assay | B | 5.56 | pEC50 | 2754.23 | nM | EC50 | Eur J Med Chem (2020) 186: 111855-111855 [PMID:31740051] |
| dihydroorotate dehydrogenase (quinone) in Mouse [GtoPdb: 2604] [UniProtKB: O35435] | ||||||||
| GtoPdb | - | - | 5.42 | pIC50 | 3800 | nM | IC50 | Am J Pathol (2010) 176: 2840-7 [PMID:20413687] |
| dihydroorotate dehydrogenase (quinone) in Rat [GtoPdb: 2604] [UniProtKB: Q63707] | ||||||||
| GtoPdb | - | - | 6.34 | pIC50 | 460 | nM | IC50 | Am J Pathol (2010) 176: 2840-7 [PMID:20413687] |
| Nuclear receptor related 1 in Human [GtoPdb: 630] [UniProtKB: P43354] | ||||||||
| GtoPdb | Determined in a Gal4-Nrr1 reporter gene assay | - | 6.4 | pEC50 | 400 | nM | EC50 | J Med Chem (2023) : |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
