(+)-sulpiride [Ligand Id: 960] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL196677 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of cloned human carbonic anhydrase II | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of catalytic domain of human recombinant carbonic anhydrase IX | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| GtoPdb | - | - | 8.22 | pKi | 6 | nM | Ki | J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand. | B | 5.57 | pKi | 2700 | nM | Ki | J Med Chem (1991) 34: 261-267 [PMID:1825115] |
| GtoPdb | - | - | 7 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| GtoPdb | - | - | 8.1 | pKi | 7.99 | nM | Ki | Mol Pharmacol (1993) 43: 749-54 [PMID:8099194] |
| D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 5.66 | pKi | 2200 | nM | Ki | Mol Pharmacol (1996) 50: 1658-64 [PMID:8967990] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
