ChEMBL ligand: CHEMBL412262 (BMS-646256, Ibipinabant, Slv319, SLV-319)
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB1 receptor/Cannabinoid CB1 receptor in Mouse [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]Arachidonic acid release in CHO cells	F	9.9	pKd	0.13	nM	Kd	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Antagonistic activity against cannabinoid receptor 1 measured by CP-55940 induced arachnoid acid release in CHO cells	F	9.9	pKd	0.13	nM	Kd	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Antagonist activity at human cannabinoid CB1 receptor expressed in CHO cells assessed as inhibition of CP-55940-induced [3H]arachidonic acid release	F	9.9	pKd	0.13	nM	Kd	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
ChEMBL	Displacement of [3H]CP-55940 from human CB1R expressed in HEK293 cells	B	8.1	pKi	8	nM	Ki	J Med Chem (2008) 51: 2115-2127 [PMID:18335976]
ChEMBL	Displacement of specific CP-55940 binding in CHO cells stably transfected with human cannabinoid receptor 1	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells	B	8.11	pKi	7.8	nM	Ki	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Binding affinity to CB1 receptor	B	8.11	pKi	7.8	nM	Ki	J Med Chem (2008) 51: 2439-2446 [PMID:18363352]
ChEMBL	Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation counting	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4183-4190 [PMID:19520572]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB1 receptor expressed in CHO cells	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
GtoPdb	Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells	-	8.11	pKi	7.8	nM	Ki	J Med Chem (2004) 47: 627-43 [PMID:14736243]
ChEMBL	Displacement of radioligand from human CB1 receptor expressed in HEK293 cells	B	8.39	pKi	4.1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1199-1206 [PMID:18083560]
ChEMBL	Displacement of [3H]SR141716 from human recombinant CB1 receptor expressed in HEK293 cells	B	8.5	pKi	3.16	nM	Ki	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Displacement of [3H]BMS-725519 from human CB1 receptor expressed in CHO cells after 90 mins by scintillation counting	B	9.38	pKi	0.42	nM	Ki	Bioorg Med Chem Lett (2011) 21: 6856-6860 [PMID:21962575]
ChEMBL	Inverse agonist activity at CB1 receptor assessed as repression of basal receptor activity by mammalian cell-based receptor selection and amplification technology method	F	7.7	pIC50	19.95	nM	IC50	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Inhibition of [3H]CP-55940 binding to human recombinant CB1 receptor in CHO cells	B	7.77	pIC50	17	nM	IC50	J Med Chem (2006) 49: 7584-7587 [PMID:17181138]
CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746]
ChEMBL	Displacement of [3H]CP55490 from CB1 receptor in mouse brain plasma membrane by radioligand displacement analysis	B	8.09	pKi	8.1	nM	Ki	J Med Chem (2023) 66: 11985-12004 [PMID:37611316]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
GtoPdb	Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor	-	5.1	pKi	7943	nM	Ki	J Med Chem (2004) 47: 627-43 [PMID:14736243]
ChEMBL	Affinity to displace CP-55940 binding from Cannabinoid receptor 2 of human expressed in CHO cells	B	5.1	pKi	7943	nM	Ki	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Binding affinity to CB2 receptor	B	5.1	pKi	7943	nM	Ki	J Med Chem (2008) 51: 2439-2446 [PMID:18363352]
ChEMBL	Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells by liquid scintillation counting	B	5.1	pKi	7943	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4183-4190 [PMID:19520572]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB2 receptor expressed in CHO cells	B	5.1	pKi	7943	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
ChEMBL	Displacement of specific CP-55940 binding in CHO cells stably transfected with human cannabinoid receptor 2	B	5.13	pKi	7493	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Displacement of [3H]SR141716 from human recombinant CB2 receptor expressed in HEK293 cells	B	5.7	pKi	1995.26	nM	Ki	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Inhibition of [3H]CP-55940 binding to human recombinant CB2 receptor in CHO cells	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2006) 49: 7584-7587 [PMID:17181138]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]