peficitinib [Ligand Id: 8315] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3137308 (Asp-015k, ASP-015K, ASP015K, JNJ-54781532, Peficitinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | J Pharmacol Sci (2017) 133: 25-33 [PMID:28117214] |
| ChEMBL | Inhibition of JAK1 (unknown origin) | B | 8.41 | pIC50 | 3.9 | nM | IC50 | J Med Chem (2015) 58: 7596-7602 [PMID:26351728] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | J Pharmacol Sci (2017) 133: 25-33 [PMID:28117214] |
| ChEMBL | Inhibition of JAK2 (unknown origin) | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2015) 58: 7596-7602 [PMID:26351728] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Inhibition of JAK3 (unknown origin) | B | 9.15 | pIC50 | 0.71 | nM | IC50 | J Med Chem (2015) 58: 7596-7602 [PMID:26351728] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | J Pharmacol Sci (2017) 133: 25-33 [PMID:28117214] |
| ChEMBL | Inhibition of Tyk2 (unknown origin) | B | 8.32 | pIC50 | 4.8 | nM | IC50 | J Med Chem (2015) 58: 7596-7602 [PMID:26351728] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
