ChEMBL ligand: CHEMBL2207198
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] There should be some charts here, you may need to enable JavaScript!
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] There should be some charts here, you may need to enable JavaScript!
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Mouse [ChEMBL: CHEMBL2189160] [GtoPdb: 2237] [UniProtKB: Q9WUN2] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
ChEMBL	Inhibition of BRSK2	B	5.72	pIC50	1900	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2	B	6.2	pIC50	630	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
GtoPdb	-	-	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL	Inhibition of IKKepsilon	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL	Inhibition of MNK1	B	4.72	pIC50	19000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora B	B	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
GtoPdb	-	-	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL	Inhibition of MARK3	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL	Inhibition of TBK1 by radiometry	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189160] [GtoPdb: 2237] [UniProtKB: Q9WUN2]
ChEMBL	Inhibition of TBK1-mediated RANTES release in LPS-stimulated mouse RAW264.7 cells compound incubated for 30 mins prior LPS challenge measured after 6 hrs by ELISA	B	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093]
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
GtoPdb	-	-	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]