ChEMBL ligand: CHEMBL2017556
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
GtoPdb	-	-	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL	Inhibition of recombinant N-terminus His6 tagged Itk (357-620) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	Inhibition of Lck autophosphorylation using [33P]ATP by scintillation counting	B	7.41	pIC50	39.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb	-	-	7.41	pIC50	39.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of recombinant N-terminus His6 tagged Syk (343 to 635) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting	B	6.45	pIC50	358.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb	-	-	6.45	pIC50	358.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
GtoPdb	-	-	7.11	pIC50	77.5	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL	Inhibition of Txk autophosphorylation using [33P]ATP by scintillation counting	B	7.11	pIC50	77.5	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]