ChEMBL ligand: CHEMBL364623
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibitory activity against Cyclin-dependent kinase 2	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
ChEMBL	Inhibition of Cdk2	B	4.6	pIC50	>25000	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL	Inhibitory activity against Cyclin-dependent kinase 4	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of Her1	B	5.28	pIC50	5200	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibition of FGFR1	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL	Inhibitory activity against HER2 kinase	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
ChEMBL	Inhibition of Her2	B	6.3	pIC50	500	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
GtoPdb	-	-	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
ChEMBL	Inhibitory activity against Fgr kinase	B	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
ChEMBL	Inhibition of Fgr	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
ChEMBL	inhibitory activity against Fyn protein kinase	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
ChEMBL	Inhibition of Fyn	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL	inhibitory activity against Hck kinase	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
ChEMBL	Inhibition of Hck	B	8.7	pIC50	2	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
ChEMBL	inhibitory activity against Janus kinase 3	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
ChEMBL	Inhibition of human Lck in presence of ATP	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL	Inhibition of murine Lck in presence of ATP	B	9.89	pKi	0.13	nM	Ki	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL	Inhibition of Lyn	B	8.4	pIC50	4	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of Src in presence of ATP	B	8.7	pIC50	<2	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
GtoPdb	-	-	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]
ChEMBL	Inhibitory activity against Src tyrosine kinase	B	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL	Inhibition of Yes	B	8.7	pIC50	2	nM	IC50	J Med Chem (2006) 49: 6819-6832 [PMID:17154512]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	inhibitory activity against Vascular endothelial growth factor receptor 2	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6066 [PMID:15546730]
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6061-6 [PMID:15546730]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]