compound 23n [PMID: 24900877] [Ligand Id: 7832] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3287898
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
  • diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Mouse [ChEMBL: CHEMBL1075284] [GtoPdb: 2821] [UniProtKB: Q9Z2A7]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Inhibition of CB1 receptor (unknown origin) B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790]
ChEMBL Inhibition of CASP8 (unknown origin) B 5.17 pIC50 6800 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Caspase 9/Caspase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2273] [GtoPdb: 1625] [UniProtKB: P55211]
ChEMBL Inhibition of CASP9 (unknown origin) B 5.3 pIC50 5000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
GtoPdb - - 7.19 pIC50 64 nM IC50 ACS Med Chem Lett (2014) 5: 544-9 [PMID:24900877]
ChEMBL Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis B 7.19 pIC50 64 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075284] [GtoPdb: 2821] [UniProtKB: Q9Z2A7]
ChEMBL Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis B 7.36 pIC50 44 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Inhibition of D2 receptor (unknown origin) B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGF receptor (unknown origin) B 5.12 pIC50 7500 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of insulin receptor (unknown origin) B 5.24 pIC50 5700 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Inhibition of prostanoid IP receptor (unknown origin) B 6 pIC50 1000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]