L-759,656 [Ligand Id: 749] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL294013 (L-759656) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Binding affinity against human cannabinoid receptor by using radioligand ([3H]CP-55940) assay. | B | 4.7 | pKi | >20000 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
| ChEMBL | Binding affinity to human CB1 receptor | B | 4.7 | pKi | >20000 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | B | 5.31 | pKi | 4888 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]CP-55940) assay. | B | 7.71 | pKi | 19.4 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
| ChEMBL | Binding affinity to human CB2 receptor | B | 7.71 | pKi | 19.4 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GtoPdb | - | - | 7.9 | pKi | 12.6 | nM | Ki |
Br J Pharmacol (1999) 126: 665-672 [PMID:10188977]; Bioorg Med Chem Lett (1996) 6: 189-194 |
| ChEMBL | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | B | 7.93 | pKi | 11.8 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
