L-759,633 [Ligand Id: 748] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL57367 (L-759633) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Binding affinity against human cannabinoid receptor by using radioligand ([3H]CP-55940) assay. | B | 4.8 | pKi | 15850 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
| ChEMBL | Binding affinity to human CB1 receptor | B | 4.8 | pKi | 15850 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | B | 5.98 | pKi | 1043 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]CP-55940) assay. | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
| ChEMBL | Binding affinity to human CB2 receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | B | 8.19 | pKi | 6.4 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| GtoPdb | - | - | 8.2 | pKi | 6.31 | nM | Ki |
Br J Pharmacol (1999) 126: 665-672 [PMID:10188977]; Bioorg Med Chem Lett (1996) 6: 189-194 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
