arachidonylcyclopropylamide [Ligand Id: 739] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL418353 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Binding affinity towards rat brain cannabinoid receptor 1 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 | B | 8.57 | pKi | 2.7 | nM | Ki | J Med Chem (2005) 48: 6423-6429 [PMID:16190768] |
| ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GtoPdb | - | - | 8.7 | pKi | - | - | - | J Pharmacol Exp Ther (1999) 289: 1427-33 [PMID:10336536] |
| ChEMBL | Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor | F | 6.4 | pEC50 | 398.11 | nM | EC50 | J Med Chem (2006) 49: 554-566 [PMID:16420041] |
| CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Binding affinity towards mouse spleen cannabinoid receptor 2 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 | B | 6.8 | pKi | 157 | nM | Ki | J Med Chem (2005) 48: 6423-6429 [PMID:16190768] |
| CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB2 receptor of rat spleen membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 6.15 | pKi | 715 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] | ||||||||
| GtoPdb | - | - | 4.87 | pEC50 | 13500 | nM | EC50 | Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
