ChEMBL ligand: CHEMBL673 (Eutonyl, Eutron, Pargyline)
aldehyde dehydrogenase 2 family member/Aldehyde dehydrogenase in Rat [ChEMBL: CHEMBL2812] [GtoPdb: 2595] [UniProtKB: P11884] There should be some charts here, you may need to enable JavaScript!
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] Monoamine oxidase A in Rat [ChEMBL: CHEMBL3358] [UniProtKB: P21396] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] Monoamine oxidase B in Rat [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aldehyde dehydrogenase 2 family member/Aldehyde dehydrogenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2812] [GtoPdb: 2595] [UniProtKB: P11884]
ChEMBL	Inhibition of Sprague-Dawley rat mitochondrial aldehyde dehydrogenase	B	5.25	pIC50	5600	nM	IC50	J Nat Prod (1997) 60: 1180-1182
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assay	B	6	pEC50	>1000	nM	EC50	J Med Chem (2021) 64: 14311-14331 [PMID:34606270]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotometric analysis	B	4.7	pIC50	>20000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 839-843 [PMID:30686752]
ChEMBL	Inhibition of recombinant human MAO-A using kynuramine as substrate by fluorescence spectroscopy	B	4.89	pIC50	13000	nM	IC50	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
ChEMBL	Inhibition of recombinant human MAO-A using kynuramine as substrate after 20 mins	B	4.89	pIC50	13000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4599-4605 [PMID:27578245]
ChEMBL	Inhibition of human recombinant monoamine oxidase-A assessed as kynuramine conversion to 6-hydroxyquinoline after 20 mins by fluorescence spectrophotometric analysis	B	4.89	pIC50	12970	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1269-1273 [PMID:23374869]
ChEMBL	Inhibition of human recombinant MAOA expressed in microsomes of baculovirus-infected insect cell using kynuramine as substrate preincubated for 20 mins followed by protein addition measured after 30 mins by fluorescence assay	B	4.96	pIC50	10900	nM	IC50	J Med Chem (2016) 59: 6791-6806 [PMID:27347731]
ChEMBL	Inhibition of human recombinant MAO-A using pargyline as incubated for 20 mins measuring increase in emission signal at 310 nm multimode plate reader assay	B	5.34	pIC50	4600	nM	IC50	Bioorg Med Chem (2021) 42: 116255-116255 [PMID:34119696]
ChEMBL	Inhibition of human recombinant MAO-A using kynuramine substrate by spectrophotometric assay	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2015) 58: 5561-5578 [PMID:26107513]
ChEMBL	Inhibition of recombinant human microsomal MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition and measured over 20 mins by amplex red reagent-based horseradish peroxidase-coupled fluorometric assay	B	5.4	pIC50	3967.9	nM	IC50	J Med Chem (2020) 63: 1361-1387 [PMID:31917923]
ChEMBL	Inhibition of human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by fluorescence-based Amplex Red MAO assay	B	5.45	pIC50	3520	nM	IC50	Bioorg Med Chem (2017) 25: 5917-5928 [PMID:28988627]
ChEMBL	Inhibition of MAOA (unknown origin) using kynuramine as substrate after 1 hr by fluorescence assay	B	5.47	pIC50	3390	nM	IC50	J Med Chem (2013) 56: 7334-7342 [PMID:24007511]
ChEMBL	Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured for 20 mins by amplex red assay	B	5.47	pIC50	3368	nM	IC50	Bioorg Med Chem (2017) 25: 633-645 [PMID:27908752]
ChEMBL	Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 10 mins followed by addition of kynuramine as substrate	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4714-4719 [PMID:27575476]
ChEMBL	Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate addition	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2018) 28: 584-588 [PMID:29395970]
ChEMBL	Inhibition of MAOA (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition	B	5.88	pIC50	1310	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
ChEMBL	Inhibition of recombinant human MAO-A assessed as reduction in H2O2 production using p-tyramine as substrate preincubated for 15 mins followed by substrate addition by Amplex red reagent based fluorescence assay	B	5.96	pIC50	1100	nM	IC50	Medchemcomm (2017) 8: 1459-1467 [PMID:30108857]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL	Inhibition of MAO-A in rat liver homogenate after 60 mins by Lineweaver-Burke plot	B	5.07	pKi	8500	nM	Ki	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Binding affinity to human recombinant microsomal MAO-B by ITC	B	6.56	pKd	275.4	nM	Kd	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition constant against human recombinant Monoamine oxidase-B	B	5.74	pKi	1800	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4438-4446 [PMID:16137882]
ChEMBL	Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	7.31	pKi	49.5	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	7.69	pKi	20.3	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of human recombinant MAOB using kynuramine as substrate incubated for 10 mins by UPLC-ESI-MS/MS analysis	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2019) 27: 2027-2040 [PMID:30975503]
ChEMBL	Inhibition of human recombinant MAOB expressed in microsomes of baculovirus-infected insect cell using kynuramine as substrate preincubated for 20 mins followed by protein addition measured after 30 mins by fluorescence assay	B	5.57	pIC50	2690	nM	IC50	J Med Chem (2016) 59: 6791-6806 [PMID:27347731]
ChEMBL	Inhibition of MAOB	B	5.59	pIC50	2600	nM	IC50	Eur J Med Chem (2009) 44: 3584-3590 [PMID:19321235]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells assessed as reduction in formation of 4-quinolinol using kynuramine as substrate preincubated with substrate for 10 mins followed by enzyme addition and measured after 20 mins by fluorescence based microplate reader assay	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem (2020) 28: 115156-115156 [PMID:31740200]
ChEMBL	Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins measuring increase in emission signal at 400 nm multimode plate reader assay	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem (2021) 42: 116255-116255 [PMID:34119696]
ChEMBL	Inhibition of human MAO-B using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by fluorescence-based Amplex Red MAO assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2017) 25: 5917-5928 [PMID:28988627]
ChEMBL	Inhibition of human MAO-B using p-tyramine as substrate assessed as production of H2O2 from p-tyramine incubated for 15 mins by Amplex Red MAO assay	B	6.7	pIC50	198.5	nM	IC50	Medchemcomm (2015) 6: 1293-1302
ChEMBL	Inhibition of recombinant human microsomal MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition and measured over 20 mins by amplex red reagent-based horseradish peroxidase-coupled fluorometric assay	B	6.71	pIC50	195.5	nM	IC50	J Med Chem (2020) 63: 1361-1387 [PMID:31917923]
ChEMBL	Inhibition of human recombinant microsomal MAO-B expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured for 20 mins by amplex red assay	B	6.71	pIC50	195	nM	IC50	Bioorg Med Chem (2017) 25: 633-645 [PMID:27908752]
ChEMBL	Inhibition of recombinant human MAO-B using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by amplex red reagent based fluorescence assay	B	6.71	pIC50	194	nM	IC50	Eur J Med Chem (2017) 138: 715-728 [PMID:28728104]
ChEMBL	Inhibition of human recombinant MAO-B using p-tyramine as substrate assessed as H2O2 production after 15 mins by fluorescence assay	B	6.72	pIC50	192	nM	IC50	Bioorg Med Chem Lett (2015) 25: 508-513 [PMID:25542589]
ChEMBL	Inhibition of recombinant human MAO-B using p-benzylamine substrate preincubated for 15 mins before substrate addition measured after 20 mins by fluorescence assay	B	6.73	pIC50	188	nM	IC50	Eur J Med Chem (2013) 62: 745-753 [PMID:23454517]
ChEMBL	Inhibition of human recombinant MAO-B using benzylamine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluorescence plate reader analysis	B	6.73	pIC50	188	nM	IC50	Bioorg Med Chem (2015) 23: 3722-3729 [PMID:25934229]
ChEMBL	Inhibition of recombinant human MAOB using benzylamine as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Amplex red reagent based fluorescence assay	B	6.73	pIC50	188	nM	IC50	Eur J Med Chem (2018) 143: 33-47 [PMID:29172081]
ChEMBL	Inhibition of human recombinant MAO-B using benzylamine as substrate preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay	B	6.73	pIC50	188	nM	IC50	Bioorg Med Chem (2013) 21: 7406-7417 [PMID:24128814]
ChEMBL	Inhibition of human recombinant microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in production of H202 using p-tyramine as substrate incubated for 30 mins followed by substrate addition by horse radish peroxidase/Amplex red reagent based fluorescence assay	B	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2019) 177: 221-234 [PMID:31151057]
ChEMBL	Inhibition of MAOB (unknown origin) using kynuramine as substrate after 1 hr by fluorescence assay	B	6.89	pIC50	130	nM	IC50	J Med Chem (2013) 56: 7334-7342 [PMID:24007511]
ChEMBL	Inhibition of human recombinant MAO-B using kynuramine substrate by spectrophotometric assay	B	6.89	pIC50	130	nM	IC50	J Med Chem (2015) 58: 5561-5578 [PMID:26107513]
ChEMBL	Inhibition of recombinant human MAO-B using p-tyramine as substrate preincubated with enzyme for 15 mins followed incubation with substrate for 20 mins by Amplex red reagent based fluorescence based analysis	B	6.92	pIC50	120	nM	IC50	RSC Med Chem (2020) 11: 225-233 [PMID:33479629]
ChEMBL	Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2018) 28: 584-588 [PMID:29395970]
ChEMBL	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 10 mins followed by substrate addition by fluorimetric analysis	B	6.97	pIC50	107.3	nM	IC50	Bioorg Med Chem (2020) 28: 115550-115550 [PMID:32503694]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 10 mins followed by addition of benzylamine as substrate	B	6.99	pIC50	103	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4714-4719 [PMID:27575476]
ChEMBL	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophotometric analysis	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2019) 29: 839-843 [PMID:30686752]
ChEMBL	Inhibition of MAOB (unknown origin) using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	7.04	pIC50	91	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells incubated for 15 mins with substrate p-Tyramine by fluorescence assay	B	7.07	pIC50	85.8	nM	IC50	Eur J Med Chem (2019) 180: 367-382 [PMID:31325784]
ChEMBL	Inhibition of human MAO-B preincubated for 5 mins followed by addition of Kynuramine substrate and measured after 30 mins by plate reader method	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2021) 211: 113112-113112 [PMID:33360800]
ChEMBL	Inhibition of recombinant human MAO-B assessed as reduction in H2O2 production using p-tyramine as substrate preincubated for 15 mins followed by substrate addition by Amplex red reagent based fluorescence assay	B	7.12	pIC50	75.2	nM	IC50	Medchemcomm (2017) 8: 1459-1467 [PMID:30108857]
ChEMBL	Inhibition of MAO-B (unknown origin)	B	8.09	pIC50	8.2	nM	IC50	Eur J Med Chem (2017) 138: 715-728 [PMID:28728104]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL	Inhibition of MAO-B in rat liver homogenate after 60 mins by Lineweaver-Burke plot	B	5.47	pKi	3360	nM	Ki	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
ChEMBL	Inhibition of MAO-B in rat liver homogenate after 60 mins by residual activity plot	B	5.41	pIC50	3850	nM	IC50	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
ChEMBL	Inhibition of MAOB in rat liver homogenates preincubated for 60 mins	B	5.41	pIC50	3850	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6362-6368 [PMID:18980841]
ChEMBL	Inhibition of rat liver MAOB after 60 mins pre-incubation	B	5.55	pIC50	2850	nM	IC50	Bioorg Med Chem (2007) 15: 5775-5786 [PMID:17611112]
GtoPdb	-	-	5.74	pIC50	1800	nM	IC50	Biochem Pharmacol (1982) 31: 3555-61 [PMID:6817759]
ChEMBL	Inhibition of Wistar rat brain MAOB using kynuramine as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by fluorescence assay	B	6.66	pIC50	220	nM	IC50	J Nat Prod (2019) 82: 785-791 [PMID:30920216]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]