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aldehyde dehydrogenase 2 family member

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Target id: 2595

Nomenclature: aldehyde dehydrogenase 2 family member

Family: 1.-.-.- Oxidoreductases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 517 12q24.12 ALDH2 aldehyde dehydrogenase 2 family member
Mouse - 519 5 F Aldh2 aldehyde dehydrogenase 2, mitochondrial
Rat - 519 12q16 Aldh2 aldehyde dehydrogenase 2 family member
Previous and Unofficial Names Click here for help
aldehyde dehydrogenase 2, mitochondrial | aldehyde dehydrogenase 2 family (mitochondrial) | aldehyde dehydrogenase 2
Database Links Click here for help
Alphafold P05091 (Hs), P47738 (Mm), P11884 (Rn)
BRENDA 1.2.1.3
CATH/Gene3D 3.40.605.10
ChEMBL Target CHEMBL1935 (Hs), CHEMBL2812 (Rn)
DrugBank Target P05091 (Hs)
Ensembl Gene ENSG00000111275 (Hs), ENSMUSG00000029455 (Mm), ENSRNOG00000037815 (Rn)
Entrez Gene 217 (Hs), 11669 (Mm), 29539 (Rn)
Human Protein Atlas ENSG00000111275 (Hs)
KEGG Enzyme 1.2.1.3
KEGG Gene hsa:217 (Hs), mmu:11669 (Mm), rno:29539 (Rn)
OMIM 100650 (Hs)
Pharos P05091 (Hs)
RefSeq Nucleotide NM_001128830 (Hs), NM_009656 (Mm), NM_032416 (Rn)
RefSeq Protein NP_001122302 (Hs), NP_033786 (Mm), NP_115792 (Rn)
UniProtKB P05091 (Hs), P47738 (Mm), P11884 (Rn)
Wikipedia ALDH2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human Mitochondrial Aldehyde Dehydrogenase complexed with agonist Alda-1
PDB Id:  3INJ
Resolution:  1.69Å
Species:  Human
References:  3
Image of receptor 3D structure from RCSB PDB
Description:  Apo form of human mitochondrial aldehyde dehydrogenase
PDB Id:  1O05
Resolution:  2.25Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 1.2.1.3 an aldehyde + H2O + NAD = a carboxylate + 2H+ + NADH

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
prunetin Small molecule or natural product Hs Inhibition 6.3 pKi 2
⤷ pKi 6.3 (Ki 4.5x10-7 M) In vitro inhibition of recombinant human mitochondrial alcohol dehydrogenase [2]
disulfiram Small molecule or natural product Approved drug Rn Inhibition 4.4 pIC50 4
⤷ pIC50 4.4 (IC50 3.64x10-5 M) [4]
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Alcohol sensitivity
Synonyms: acetaldehyde dehydrogenase deficiency
alcohol flush reaction
OMIM: 610251
Role:  Mutation in ALDH2 is associated with acute sensitivity to alcohol.

References

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1. Hurley TD, Perez-Miller S, Breen H. (2001) Order and disorder in mitochondrial aldehyde dehydrogenase. Chem Biol Interact, 130-132 (1-3): 3-14. [PMID:11306026]

2. Lowe ED, Gao GY, Johnson LN, Keung WM. (2008) Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem, 51 (15): 4482-7. [PMID:18613661]

3. Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. (2010) Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol, 17 (2): 159-64. [PMID:20062057]

4. Shen ML, Lipsky JJ, Naylor S. (2000) Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde dehydrogenase. Biochem Pharmacol, 60 (7): 947-53. [PMID:10974203]

How to cite this page

1.-.-.- Oxidoreductases: aldehyde dehydrogenase 2 family member. Last modified on 27/02/2018. Accessed on 12/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2595.