norgestimate [Ligand Id: 7091] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1200934 (Dexnorgestrel acetime, Norgestimate, NSC-759159, ORF 10131, ORF-10131, RWJ 10131, RWJ-10131) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507] | ||||||||
| GtoPdb | Norgestimate-induced inhibition of hTRPC3-mediated Ca2+ entry in transfected CHO cells stimulated with the OAG diacylglycerol analog. | - | 5.52 | pKi | 3000 | nM | Ki | PLoS ONE (2012) 7: e35393 [PMID:22530015] |
| TRPC6 in Human [GtoPdb: 491] [UniProtKB: Q9Y210] | ||||||||
| GtoPdb | Norgestimate-induced inhibition of hTRPC6-mediated Ca2+ entry in transfected HEK-FITR cells stimulated with the OAG diacylglycerol analog. | - | 5.28 | pIC50 | 5200 | nM | IC50 | PLoS ONE (2012) 7: e35393 [PMID:22530015] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
