romidepsin [Ligand Id: 7006] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL343448 (Depsipeptide, FK-228, FK228, FR-901228, FR901228, Istodax, NSC-630176, Romidepsin, Romidepsina, Romidepsine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
| ChEMBL | Inhibition of BRD4 (unknown origin) | B | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4051-4055 [PMID:28765013] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| GtoPdb | - | - | 11.82 | pKi | 0 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC1 after 60 mins by fluorescence assay | B | 5.98 | pIC50 | 1050 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 1 (C151S) | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant human HDAC1 | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 375-379 [PMID:26706171] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 1 | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of HDAC1 by fluorimetric assay | B | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| ChEMBL | Inhibition of HDAC1 in presence of DTT | B | 8.4 | pIC50 | 3.97 | nM | IC50 | J Med Chem (2007) 50: 5720-5726 [PMID:17958342] |
| ChEMBL | Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Eur J Med Chem (2013) 60: 295-304 [PMID:23313638] |
| ChEMBL | Inhibition of human HDAC1 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Eur J Med Chem (2014) 76: 301-313 [PMID:24589486] |
| ChEMBL | Inhibition of HDAC1 by fluorimetric assay in presence of DTT | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of human HDAC1 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreitol | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2014) 22: 3850-3855 [PMID:24997578] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| ChEMBL | Inhibition of human recombinant HDAC1 after 1 hr by luminescence assay | B | 9.51 | pIC50 | 0.31 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of recombinant HDAC1 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 9.7 | pIC50 | 0.2 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells. | B | 4.44 | pEC50 | 36000 | nM | EC50 | J Med Chem (2003) 46: 4826-4829 [PMID:14584932] |
| histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC10 after 60 mins by fluorescence assay | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC11 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assay | B | 9.52 | pIC50 | 0.3 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 1/Histone deacetylase 1/Nuclear receptor corepressor 2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885590] [GtoPdb: 2658] [UniProtKB: Q13547, Q9Y618] | ||||||||
| GtoPdb | - | - | 11.82 | pKi | 0 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC1/NCOR2 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 5.17 | pIC50 | 6700 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| GtoPdb | - | - | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC2 | B | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 10.42 | pKi | 0.04 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC2 after 60 mins by fluorescence assay | B | 5.22 | pIC50 | 6070 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 2 | B | 7.33 | pIC50 | 47 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 9 | pIC50 | 1 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9 | pIC50 | 1 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 2/Histone deacetylase 2/Nuclear receptor corepressor 2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885591] [GtoPdb: 2616] [UniProtKB: Q92769, Q9Y618] | ||||||||
| GtoPdb | - | - | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC2/NCOR2 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC3 | B | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC3 after 60 mins by fluorescence assay | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 3/Histone deacetylase 3/NCoR1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038484] [GtoPdb: 2617] [UniProtKB: O15379, O75376] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 9.82 | pKi | 0.15 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 7.6 | pKi | 24.9 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 6.83 | pIC50 | 146.9 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 1 mM H2O2 (Rvb = 0.018 uM) | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0.4 mM H2O2 (Rvb = 0.018 uM) | B | 7.41 | pIC50 | 39 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0.2 mM H2O2 (Rvb = 0.018 uM) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/NCOR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | Inhibition of human HDAC4 | B | 7.69 | pKi | 20.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC4 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 7.69 | pKi | 20.5 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 7.69 | pKi | 20.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC4 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC4 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of human recombinant HDAC4 after 1 hr by luminescence assay | B | 5.06 | pIC50 | 8670 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of HDAC4 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 6.19 | pIC50 | 647 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| ChEMBL | Inhibition of HDAC4 by fluorimetric assay | B | 6.29 | pIC50 | 510 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of Histone deacetylase 4 in mammalian cells. | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2003) 46: 4826-4829 [PMID:14584932] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 4 | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of human HDAC5 | B | 6.26 | pKi | 550 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC5 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 6.26 | pKi | 550 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 6.26 | pKi | 550 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC5 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.52 | pKi | 300.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC6 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 8.02 | pKi | 9.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC6 | B | 8.02 | pKi | 9.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 6 | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant human HDAC6 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 5.8 | pIC50 | 1595 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC6 after 60 mins by fluorescence assay | B | 5.91 | pIC50 | 1220 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC6 in presence of DTT | B | 6.1 | pIC50 | 787 | nM | IC50 | J Med Chem (2007) 50: 5720-5726 [PMID:17958342] |
| ChEMBL | Inhibition of human recombinant HDAC6 after 1 hr by luminescence assay | B | 6.17 | pIC50 | 670 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of HDAC6 by fluorimetric assay in presence of DTT | B | 6.21 | pIC50 | 620 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 6.55 | pIC50 | 281 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| ChEMBL | Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 6.7 | pIC50 | 200 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of recombinant human HDAC6 | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 375-379 [PMID:26706171] |
| histone deacetylase 6/Histone deacetylase 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2878] [GtoPdb: 2618] [UniProtKB: Q9Z2V5] | ||||||||
| ChEMBL | Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 6.41 | pIC50 | 390 | nM | IC50 | Eur J Med Chem (2013) 60: 295-304 [PMID:23313638] |
| ChEMBL | Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 6.41 | pIC50 | 390 | nM | IC50 | Eur J Med Chem (2014) 76: 301-313 [PMID:24589486] |
| ChEMBL | Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreitol | B | 9.2 | pIC50 | 0.63 | nM | IC50 | Bioorg Med Chem (2014) 22: 3850-3855 [PMID:24997578] |
| histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] | ||||||||
| GtoPdb | - | - | 5.9 | pKi | 1250 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC7 | B | 5.9 | pKi | 1250 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC7 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 5.9 | pKi | 1250 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC7 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC7 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Activity of human HDAC8 | B | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC8 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 9.82 | pKi | 0.15 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC8 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC8 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] | ||||||||
| ChEMBL | Inhibition of human HDAC9 | B | 5.96 | pKi | 1100 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC9 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 5.96 | pKi | 1100 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC9 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC9 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
