FR173657 [Ligand Id: 674] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL130517 (FK-3657) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | 7.95 | nM | IC50 | Mol Pharmacol (1997) 51: 171-6 [PMID:9203620] |
| ChEMBL | Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%. | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (1998) 41: 4062-4079 [PMID:9767643] |
| ChEMBL | Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells. | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (1998) 41: 4587-4598 [PMID:9804698] |
| ChEMBL | Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cells | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2009) 52: 4370-4379 [PMID:19552431] |
| GtoPdb | - | - | 8.2 | pA2 | - | - | - | Hypertension (1997) 29: 951-6 [PMID:9095082] |
| Bradykinin B2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4111] [UniProtKB: O70526] | ||||||||
| ChEMBL | Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%. | B | 9.34 | pIC50 | 0.46 | nM | IC50 | J Med Chem (1998) 41: 4062-4079 [PMID:9767643] |
| ChEMBL | Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations | B | 9.34 | pIC50 | 0.46 | nM | IC50 | J Med Chem (1998) 41: 4587-4598 [PMID:9804698] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
