ChEMBL ligand: CHEMBL590799 (Camostat)
cathepsin L/Cathepsin L in Human [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!
Hepatocyte growth factor activator in Human [ChEMBL: CHEMBL3351190] [UniProtKB: Q04756] There should be some charts here, you may need to enable JavaScript!
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] There should be some charts here, you may need to enable JavaScript!
MATE2/Multidrug and toxin extrusion protein 2 in Human [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Serine protease hepsin in Human [ChEMBL: CHEMBL2079849] [UniProtKB: P05981] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 2/Transmembrane protease serine 2 in Human [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393] There should be some charts here, you may need to enable JavaScript!
serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL	Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay	B	5	pIC50	10000	nM	IC50	J Med Chem (2020) 63: 12256-12274 [PMID:32539378]
Hepatocyte growth factor activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351190] [UniProtKB: Q04756]
ChEMBL	Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to cromogenic substrate addition by spectrophotometry	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem (2015) 23: 2328-2343 [PMID:25882520]
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	5.54	pIC50	2900	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
ChEMBL	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	4.9	pIC50	12700	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	4.7	pIC50	>20000	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
Serine protease hepsin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079849] [UniProtKB: P05981]
ChEMBL	Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Boc-QRR-AMC as substrate after 15 mins by automated fluorescence assay	B	7.54	pIC50	29	nM	IC50	J Med Chem (2018) 61: 4335-4347 [PMID:29701962]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	B	4.78	pIC50	16500	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Inhibition of thrombin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate by fluorescence plate reader analysis	B	6.11	pIC50	780	nM	IC50	Eur J Med Chem (2019) 176: 187-194 [PMID:31103899]
transmembrane serine protease 2/Transmembrane protease serine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393]
GtoPdb	Inhibition of TMPRSS2-dependent MERS-S-mediated membrane fusion in an in vitro reporter assay.	-	6	pIC50	1000	nM	IC50	Antimicrob Agents Chemother (2016) 60: 6532-6539 [PMID:27550352]
ChEMBL	Inhibition of human TMPRSS2-mediated SARS-CoV-2 entry into human Caco-2 cells	B	6	pEC50	1000	nM	EC50	J Med Chem (2020) 63: 13205-13227 [PMID:32845145]
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
GtoPdb	-	-	7.3	pIC50	50.6	nM	IC50	J Med Chem (1995) 38: 2521-3 [PMID:7629790]
ChEMBL	Inhibition Assay: The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M Tris (pH 8.0), 0.15 M NaCl, 10 mM CaCl2, 0.05% Brij38) (B). The r-h trypsin was diluted with a buffer to 0.088 ug/mL, and the m-trypsin was diluted with a buffer to 1/50 (C). The dilution ratio of the m-trypsin (1/50) was set to exhibit the same activity as the 0.088 ug/mL r-h trypsin as determined by kinetic analysis. The substrate solution of a substrate for the enzyme reaction, BZiPAR, (Rhodamine Reference Substrate) was diluted with a buffer to 5 umol/L (D). B; 5 uL, C; 5 uL, and D; 10 uL were added to a 384-plate, and incubated at room temperature for 30 minutes. The fluorescent signals were detected with Ex/Em = 497/520 using Tecan Safire Fluorometer. The compound was reviewed from 2500 nM to its 3-fold value, 0.0075 nM, at 12 concentrations, and the inhibitory rate of each compound was calculated.	B	8.34	pIC50	4.6	nM	IC50	US-9199927-B2. Guanidinobenzoic acid compound (2015)

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]