[Leu8,des-Arg9]bradykinin [Ligand Id: 641] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL80472 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663] | ||||||||
| ChEMBL | Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin. | B | 6.42 | pKi | 382 | nM | Ki | J Med Chem (2000) 43: 2382-2386 [PMID:10882364] |
| GtoPdb | - | - | 7.2 | pKi | - | - | - |
J Biol Chem (1997) 272: 11420-5 [PMID:9111052]; J Biol Chem (1994) 269: 21583-21586 [PMID:8063797]; Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787]; Br J Pharmacol (1997) 122: 393-9 [PMID:9313952]; Mol Pharmacol (1997) 51: 171-6 [PMID:9203620] |
| B1 receptor in Mouse [GtoPdb: 41] [UniProtKB: Q61125] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | Immunopharmacology (1996) 33: 1-8 [PMID:8856107] |
| GtoPdb | - | - | 7.3 | pEC50 | - | - | - | Can J Physiol Pharmacol (1997) 75: 735-740 [PMID:9276157] |
| GtoPdb | - | - | 6.9 | pA2 | - | - | - | Can J Physiol Pharmacol (1995) 73: 1759-64 [PMID:8834490] |
| B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583] | ||||||||
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787] |
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| ChEMBL | Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin | B | 8 | pKi | >10 | nM | Ki | J Med Chem (2000) 43: 2382-2386 [PMID:10882364] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
