ChEMBL ligand: CHEMBL8320
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B/Amine oxidase [flavin-containing] B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] There should be some charts here, you may need to enable JavaScript!
Caspase 1/Caspase-1 in Human [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Cholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 2/Cocaine esterase in Human [ChEMBL: CHEMBL3180] [GtoPdb: 3298] [UniProtKB: O00748] There should be some charts here, you may need to enable JavaScript!
Dihydroorotate dehydrogenase (quinone), mitochondrial in Schistosoma mansoni [ChEMBL: CHEMBL4523950] [UniProtKB: G4VFD7] There should be some charts here, you may need to enable JavaScript!
Dual specificity protein phosphatase 1 in Mouse [ChEMBL: CHEMBL5623] [UniProtKB: P28563] There should be some charts here, you may need to enable JavaScript!
Dual specificity protein phosphatase 6 in Rat [ChEMBL: CHEMBL5511] [UniProtKB: Q64346] There should be some charts here, you may need to enable JavaScript!
MDM2 proto-oncogene/E3 ubiquitin-protein ligase Mdm2 in Human [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 1/Liver carboxylesterase 1 in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141] Liver carboxylesterase 1 in Rabbit [ChEMBL: CHEMBL2623] [UniProtKB: P12337] There should be some charts here, you may need to enable JavaScript!
M-phase inducer phosphatase 2 in Human [ChEMBL: CHEMBL4804] [UniProtKB: P30305] There should be some charts here, you may need to enable JavaScript!
TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition constant against human Acetylcholinesterase (hAcChE) using acetylthiocholine (AcTCh) as substrate	B	6.02	pKi	955	nM	Ki	J Med Chem (2005) 48: 2906-2915 [PMID:15828829]
Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Competitive inhibition of human brain mitochondria MAO-A using kynuramine as substrate by Lineweaver-Burk analysis	B	5.02	pKi	9620	nM	Ki	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
ChEMBL	Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy	B	5.32	pIC50	4820	nM	IC50	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
Monoamine oxidase B/Amine oxidase [flavin-containing] B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Non-competitive inhibition of human brain mitochondria MAO-B using kynuramine as substrate by Lineweaver-Burk analysis	B	4.69	pKi	20300	nM	Ki	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy	B	4.99	pIC50	10200	nM	IC50	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL	Inhibitory activity against IL-1 beta converting enzyme was evaluated.	B	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1883-1886 [PMID:9873452]
butyrylcholinesterase/Cholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL	Inhibition constant against human Butyrylcholinesterase (hBuChE) using butyrylthiocholine (BuTCh) as substrate	B	5.69	pKi	2050	nM	Ki	J Med Chem (2005) 48: 2906-2915 [PMID:15828829]
carboxylesterase 2/Cocaine esterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3180] [GtoPdb: 3298] [UniProtKB: O00748]
ChEMBL	Inhibition constant against human intestinal carboxylesterase 2 (hiCE) using nitrophenyl acetate (o-NPA) as substrate	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 2906-2915 [PMID:15828829]
Dihydroorotate dehydrogenase (quinone), mitochondrial in Schistosoma mansoni (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523950] [UniProtKB: G4VFD7]
ChEMBL	Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assay	B	5.06	pIC50	8800	nM	IC50	Eur J Med Chem (2019) 167: 357-366 [PMID:30776695]
Dual specificity protein phosphatase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5623] [UniProtKB: P28563]
ChEMBL	Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 2276-2281 [PMID:19028102]
Dual specificity protein phosphatase 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5511] [UniProtKB: Q64346]
ChEMBL	Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 2276-2281 [PMID:19028102]
MDM2 proto-oncogene/E3 ubiquitin-protein ligase Mdm2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987]
ChEMBL	Inhibition of biotin-labelled p53 binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance method	B	4.86	pIC50	13900	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2571-2574 [PMID:28400230]
carboxylesterase 1/Liver carboxylesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
ChEMBL	Inhibition constant against human liver carboxylesterase 1 (hCE1) using nitrophenyl acetate (o-NPA) as substrate	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 2906-2915 [PMID:15828829]
Liver carboxylesterase 1 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2623] [UniProtKB: P12337]
ChEMBL	Inhibition constant against rabbit liver carboxylesterase (rCE) using nitrophenyl acetate (o-NPA) as substrate	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 2906-2915 [PMID:15828829]
M-phase inducer phosphatase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
ChEMBL	Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 2276-2281 [PMID:19028102]
TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762]
GtoPdb	Calcium imaging	-	6.4	pEC50	-	-	-	Nat Commun (2011) 2: 551 [PMID:22109525]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]