kenpaullone [Ligand Id: 6000] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL296586 (Kenpaullone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Inhibition of CK2 | B | 4.7 | pIC50 | 20000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| Casein kinase I isoform alpha in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781858] [UniProtKB: O19175] | ||||||||
| ChEMBL | Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| cyclin dependent kinase 9/CDK9/Cyclin T in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL5291961] [GtoPdb: 1981] [UniProtKB: O60563, O60583, P50750] | ||||||||
| ChEMBL | Inhibition of CDK9/Cyclin T (unknown origin) | B | 7.19 | pIC50 | 64 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
| ChEMBL | Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) substrate after 30 mins by scintillation counting | B | 7.19 | pIC50 | 64 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| cyclin dependent kinase 1 in spiny starfish [GtoPdb: 1961] | ||||||||
| GtoPdb | CDK1/cyclin B complex | - | 6.4 | pIC50 | 400 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1999) 42: 2909-2919 [PMID:10425100] |
| cyclin dependent kinase 1 in spiny starfish [GtoPdb: 1961] | ||||||||
| GtoPdb | CDK1/cyclin B complex | - | 6.4 | pIC50 | 400 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibition of human cyclin-dependent kinase 1-cyclin B | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 413-416 [PMID:14698171] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 1-cyclin B from M phase starfish (Marthasterias glacialis) oocytes | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2003) 46: 876-879 [PMID:12593668] |
| ChEMBL | Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysis | B | 6.4 | pIC50 | 400 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytes | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 567-569 [PMID:10741555] |
| ChEMBL | Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte | B | 6.4 | pIC50 | 400 | nM | IC50 | Eur J Med Chem (2010) 45: 335-342 [PMID:19906467] |
| ChEMBL | Inhibition of CDK1/cyclinB | B | 6.4 | pIC50 | 400 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
| ChEMBL | Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes | B | 6.4 | pIC50 | 399.94 | nM | IC50 | J Med Chem (2004) 47: 22-36 [PMID:14695817] |
| cyclin dependent kinase 1 in spiny starfish [GtoPdb: 1961] | ||||||||
| GtoPdb | CDK1/cyclin B complex | - | 6.4 | pIC50 | 400 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting | B | 6.4 | pIC50 | 400 | nM | IC50 | Eur J Med Chem (2010) 45: 4316-4330 [PMID:20638755] |
| ChEMBL | Inhibition of CDK1/cyclin B | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| ChEMBL | Inhibition of GST-tagged CDK1/cyclin B (unknown origin) expressed in Escherichia coli | B | 6.4 | pIC50 | 400 | nM | IC50 | Eur J Med Chem (2017) 142: 244-265 [PMID:28803677] |
| cyclin dependent kinase 2 in spiny starfish [GtoPdb: 1973] | ||||||||
| GtoPdb | CDK2/cyclin A complex | - | 6.17 | pIC50 | 680 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| ChEMBL | Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counting | B | 6.11 | pIC50 | 780 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| ChEMBL | Inhibition of CDK2/cyclin A | B | 6.17 | pIC50 | 680 | nM | IC50 | Eur J Med Chem (2012) 56: 246-253 [PMID:22995819] |
| ChEMBL | Inhibition of CDK2/Cyclin A (unknown origin) | B | 6.17 | pIC50 | 680 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| cyclin dependent kinase 2 in spiny starfish [GtoPdb: 1973] | ||||||||
| GtoPdb | CDK2/cyclin A complex | - | 6.17 | pIC50 | 680 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) | B | 5.12 | pIC50 | 7500 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| ChEMBL | Inhibition of CDK4/Cyclin D1 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counting | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 5 (CDK5) | B | 6.07 | pIC50 | 850 | nM | IC50 | J Med Chem (2003) 46: 876-879 [PMID:12593668] |
| ChEMBL | Inhibition of human Cyclin-dependent kinase 5-p35nck5a | B | 6.07 | pIC50 | 850 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 413-416 [PMID:14698171] |
| ChEMBL | Inhibition of recombinant CDK5/p25 expressed in Escherichia coli | B | 6.07 | pIC50 | 850 | nM | IC50 | J Med Chem (2008) 51: 2196-2207 [PMID:18345612] |
| ChEMBL | Inhibition of CDK5/p25 (unknown origin) | B | 6.07 | pIC50 | 850 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 5-p35nck5a | B | 6.07 | pIC50 | 849.18 | nM | IC50 | J Med Chem (2004) 47: 22-36 [PMID:14695817] |
| cyclin dependent kinase 5 in Bovine [GtoPdb: 1977] | ||||||||
| GtoPdb | CDK5/p25 complex | - | 6.07 | pIC50 | 850 | nM | IC50 | Cancer Res (1999) 59: 2566-9 [PMID:10363974] |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Inhibition of CLK1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| ChEMBL | Inhibition of CLK1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470] | ||||||||
| ChEMBL | Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin basic protein after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Inhibition of DYRK1A (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| Glycogen synthase kinase 3 in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781857] [UniProtKB: O77344] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum GSK3 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4940-4944 [PMID:20621478] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of GSK3-beta | B | 6.64 | pIC50 | 230 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2017) 60: 8482-8514 [PMID:29016121] |
| ChEMBL | Inhibition of Glycogen synthase kinase-3 beta purified from insect sf9 cells | B | 7.64 | pIC50 | 23.01 | nM | IC50 | J Med Chem (2004) 47: 22-36 [PMID:14695817] |
| ChEMBL | Inhibition of GSK3-beta | B | 7.64 | pIC50 | 23 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
| ChEMBL | Inhibition of GSK3beta (unknown origin) expressed in sf9 cells after 30 mins by scintillation counting analysis in presence of [gamma-32P]ATP | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539] |
| ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2021) 210: 112949-112949 [PMID:33097303] |
| ChEMBL | Inhibition of human glycogen synthase kinase-3 beta | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 413-416 [PMID:14698171] |
| ChEMBL | Inhibition of GSK3-beta expressed in insect Sf9 cells | B | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2010) 45: 335-342 [PMID:19906467] |
| GtoPdb | - | - | 7.64 | pIC50 | 23 | nM | IC50 | J Biol Chem (2001) 276: 251-60 [PMID:11013232] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3669] [GtoPdb: 2030] [UniProtKB: P18266] | ||||||||
| ChEMBL | Inhibition of recombinant recombinant rat GSK3beta using GS-1 peptide as substrate in presence of [gamma-32P]ATP measured after 30 mins incubation by scintillation counting analysis | B | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 0.1 uM ATP | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 2433-2442 [PMID:20170163] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Inhibition of ERK1 | B | 4.7 | pIC50 | 20000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of Erk1 (unknown origin) | B | 4.7 | pIC50 | 20000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| ChEMBL | Inhibition of Erk1 (unknown origin) | B | 7.7 | pIC50 | 20 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of ERK2 | B | 5.05 | pIC50 | 9000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of Erk2 (unknown origin) | B | 5.05 | pIC50 | 9000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| ChEMBL | Inhibition of Erk2 (unknown origin) | B | 8.05 | pIC50 | 9 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] | ||||||||
| ChEMBL | Inhibition of human recombinant SIRT2 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2006) 49: 7307-7316 [PMID:17149860] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | Inhibitory activity against Plasmodium falciparum W2 | F | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2003) 46: 3877-3882 [PMID:12930149] |
| ChEMBL | Inhibitory activity against Plasmodium falciparum D6 | F | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2003) 46: 3877-3882 [PMID:12930149] |
| Protein kinase Pfmrk in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4090] [UniProtKB: P90584] | ||||||||
| ChEMBL | Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, Pfmrk | B | 4.82 | pIC50 | 15000 | nM | IC50 | J Med Chem (2003) 46: 3877-3882 [PMID:12930149] |
| ChEMBL | Inhibition of Plasmodium falciparum cyclin-dependent kinase | B | 4.82 | pIC50 | 15000 | nM | IC50 | J Med Chem (2004) 47: 5418-5426 [PMID:15481979] |
| CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
| ChEMBL | Inhibition of SARS-CoV-2 M-protease | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2022) 65: 955-982 [PMID:34081439] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 0.1 uM ATP | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 2433-2442 [PMID:20170163] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Inhibition of c-Raf (unknown origin) | B | 4.42 | pIC50 | 38000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Inhibition of Lck | B | 6.33 | pIC50 | 470 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of c-Src | B | 4.82 | pIC50 | 15000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of c-Src (unknown origin) | B | 4.82 | pIC50 | 15000 | nM | IC50 | Eur J Med Chem (2021) 220: 113445-113445 [PMID:33901899] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 0.1 uM ATP | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 2433-2442 [PMID:20170163] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
