roxindole [Ligand Id: 52] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL431367 (Roxindole)
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
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  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand B 5 pKi >10000 nM Ki J. Med. Chem. (1996) 39: 3179-3187 [PMID:8759640]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Compound was evaluated for effective concentration in vivo for Dopamine receptor D2 mitogenesis. (95% confidence intervals) F 9.43 pEC50 0.37 nM EC50 J. Med. Chem. (1996) 39: 3179-3187 [PMID:8759640]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL In vitro binding affinity for dopamine receptor D2 on rat striatal membranes by [3H]spiperone displacement. B 7.85 pKi 14 nM Ki J. Med. Chem. (1997) 40: 250-259 [PMID:9003524]
ChEMBL Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]spiperone displacement. B 8.04 pKi 9.1 nM Ki J. Med. Chem. (1996) 39: 3179-3187 [PMID:8759640]
ChEMBL Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes [3H]ADTN, a dopamine agonist F 9.06 pKi 0.88 nM Ki J. Med. Chem. (1992) 35: 4020-4026 [PMID:1359142]
ChEMBL Compound was evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes 3[H]spiperone, a dopamine antagonist F 8.23 pIC50 5.95 nM IC50 J. Med. Chem. (1992) 35: 4020-4026 [PMID:1359142]
ChEMBL Displacement of [3H]spiperone from dopamine D2 receptor of rat striatal membranes B 8.25 pIC50 5.6 nM IC50 J. Med. Chem. (2004) 47: 4677-4683 [PMID:15341483]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 8.9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]spiperone as radioligand B 9.4 pKi 0.4 nM Ki J. Med. Chem. (1996) 39: 3179-3187 [PMID:8759640]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity against human Dopamine receptor D4 in CHO-K1 cells using [3H]spiperone as radioligand B 7.62 pKi 24 nM Ki J. Med. Chem. (1996) 39: 3179-3187 [PMID:8759640]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 9.9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Inhibition of 5HT1A receptor B 9.1 pIC50 0.8 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1118-1123 [PMID:20022748]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells B 9.1 pIC50 0.8 nM IC50 J. Med. Chem. (2004) 47: 4677-4683 [PMID:15341483]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 6 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 7.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 7.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 6.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 8.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 8.8 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]