bromoenol lactone [Ligand Id: 5149] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL6206 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| iPLA2-G6/85/88 kDa calcium-independent phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3213] [GtoPdb: 1431] [UniProtKB: O60733] | ||||||||
| ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
| ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
| Fatty acid amide hydrolase/Fatty-acid amide hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Irreversible inhibition of fatty acid amide hydrolase | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| Fatty acid amide hydrolase/Fatty-acid amide hydrolase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of FAAH in rat brain assessed as hydrolysis of anandamide | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TRPC5/Short transient receptor potential channel 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250411] [GtoPdb: 490] [UniProtKB: Q9UL62] | ||||||||
| ChEMBL | Antagonist activity at TRPC5 (unknown origin) assessed as inhibition of channel activity | B | 4.97 | pIC50 | 10600 | nM | IC50 | Eur J Med Chem (2024) 265: 116066-116066 [PMID:38185057] |
| TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29] | ||||||||
| GtoPdb | - | - | 4.97 | pIC50 | - | - | - | J Pharmacol Exp Ther (2011) 339: 329-40 [PMID:21795434] |
| TRPC6/Short transient receptor potential channel 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417347] [GtoPdb: 491] [UniProtKB: Q9Y210] | ||||||||
| ChEMBL | Antagonist activity at TRPC6 (unknown origin) assessed as inhibition of channel activity | B | 5.14 | pIC50 | 7200 | nM | IC50 | Eur J Med Chem (2024) 265: 116066-116066 [PMID:38185057] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
