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ChEMBL ligand: CHEMBL1459962 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human recombinant acetylcholinesterase expressed in HEK-293 cells using AMTch as substrate after 30 mins by spectrophotometric method | B | 6.08 | pIC50 | 840 | nM | IC50 | J Med Chem (2019) 62: 7589-7602 [PMID:30943030] |
TRPC4 in Human [GtoPdb: 489] [UniProtKB: Q9UBN4] | ||||||||
GtoPdb | - | - | 5.5 | pIC50 | 2900 | nM | IC50 | J Biol Chem (2011) 286: 33436-46 [PMID:21795696] |
TRPC4/Short transient receptor potential channel 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741219] [GtoPdb: 489] [UniProtKB: Q9QUQ5] | ||||||||
GtoPdb | - | - | 5.54 | pIC50 | 2910 | nM | IC50 | J Biol Chem (2011) 286: 33436-46 [PMID:21795696] |
ChEMBL | Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced current by QPatch clamp assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (2019) 62: 7589-7602 [PMID:30943030] |
ChEMBL | Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced intracellular calcium level in presence of mu-opioid receptor agonist DAMGO by Fluo-4AM dye based fluorescence assay | B | 6.02 | pIC50 | 960 | nM | IC50 | J Med Chem (2019) 62: 7589-7602 [PMID:30943030] |
TRPC6/Short transient receptor potential channel 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795081] [GtoPdb: 491] [UniProtKB: Q61143] | ||||||||
ChEMBL | Inhibition of HA-tagged mouse TRPC6 expressed in HEK293 cells assessed as reduction in acetylcholine-induced membrane potential by FLIPR membrane potential dye based assay | B | 4.75 | pIC50 | 17900 | nM | IC50 | J Med Chem (2019) 62: 7589-7602 [PMID:30943030] |
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62] | ||||||||
GtoPdb | - | - | 5 | pIC50 | ~10000 | nM | IC50 | J Biol Chem (2011) 286: 33436-46 [PMID:21795696] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]