morin [Ligand Id: 411] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL28626 (NSC-19801) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6] | ||||||||
| ChEMBL | Inhibition of FabG | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. | B | 4.86 | pKi | 13800 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| GtoPdb | - | - | 4.9 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. | B | 4.47 | pKi | 34000 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265] | ||||||||
| ChEMBL | Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry | B | 1.6 | pIC50 | 1.6 | - | logIC50 | Med Chem Res (2012) 21: 3984-3993 |
| ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] | ||||||||
| ChEMBL | Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem (2011) 19: 2090-2102 [PMID:21354800] |
| ChEMBL | Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining | B | 4.68 | pIC50 | 21000 | nM | IC50 | Bioorg Med Chem (2011) 19: 2090-2102 [PMID:21354800] |
| Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assay | B | 4.52 | pIC50 | 30300 | nM | IC50 | Bioorg Med Chem (2016) 24: 304-313 [PMID:26719209] |
| ChEMBL | Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation after 24 hrs by thioflavin-T fluorescence method | B | 5.07 | pIC50 | 8500 | nM | IC50 | Eur J Med Chem (2020) 192: 112193-112193 [PMID:32151835] |
| beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| ChEMBL | Inhibition of BACE1 (unknown origin) | B | 4.66 | pIC50 | 21700 | nM | IC50 | Med Chem Res (2013) 22: 3061-3075 |
| ChEMBL | Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay | B | 4.91 | pIC50 | 12300 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2945-2948 [PMID:21511472] |
| casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
| ChEMBL | Inhibition of recombinant human CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2015) 58: 7400-7408 [PMID:26322379] |
| death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355] | ||||||||
| ChEMBL | Inhibition of DAPK1 (unknown origin) using ZIPtide as substrate by fluorescence assay in presence of ATP, MgCl2 | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2015) 58: 7400-7408 [PMID:26322379] |
| ChEMBL | Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2015) 58: 7400-7408 [PMID:26322379] |
| DNA-3-methyladenine glycosylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396943] [UniProtKB: P29372] | ||||||||
| ChEMBL | Inhibition of human AAG using HXO2/Loop01 oligonucleotide as substrate incubated for 2 hrs by colorimetric based microplate assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2020) 28: 115507-115507 [PMID:32327352] |
| Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5] | ||||||||
| ChEMBL | Inhibition of FabI | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7] | ||||||||
| ChEMBL | Inhibition of FabZ | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760] | ||||||||
| ChEMBL | Inhibition constant of compound against binding of Yeast Glyoxalase I | B | 4.52 | pKi | 30199.52 | nM | Ki | J Med Chem (1988) 31: 1396-1406 [PMID:3290487] |
| GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
| ChEMBL | Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins | B | 5.8 | pIC50 | 1600 | nM | IC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| ChEMBL | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay | F | 4.95 | pEC50 | 11200 | nM | EC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| ChEMBL | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay | F | 5.88 | pEC50 | 1330 | nM | EC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] | ||||||||
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis | B | 5.28 | pIC50 | 5200 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
| SET domain containing 7, histone lysine methyltransferase/Histone-lysine N-methyltransferase SETD7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5523] [GtoPdb: 2703] [UniProtKB: Q8WTS6] | ||||||||
| ChEMBL | Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and biotinylated Histone H3 (1-50) peptide measured after 30 mins by AlphaLISA assay relative to control | B | 5.22 | pIC50 | 6020 | nM | IC50 | Bioorg Med Chem (2020) 28: 115372-115372 [PMID:32088124] |
| HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] | ||||||||
| ChEMBL | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
| Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] | ||||||||
| ChEMBL | IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage | B | 4.12 | pIC50 | 76500 | nM | IC50 | J Med Chem (1995) 38: 890-897 [PMID:7699704] |
| ChEMBL | IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration | B | 4.5 | pIC50 | 31700 | nM | IC50 | J Med Chem (1995) 38: 890-897 [PMID:7699704] |
| Islet amyloid polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914266] [UniProtKB: P10997] | ||||||||
| ChEMBL | Inhibition of islet amyloid polypeptide (unknown origin) aggregation after 24 hrs by thioflavin T based fluorescence assay | B | 5.11 | pIC50 | 7800 | nM | IC50 | J Nat Prod (2021) 84: 1096-1103 [PMID:33600175] |
| Low molecular weight phosphotyrosine protein phosphatase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075054] [UniProtKB: P11064] | ||||||||
| ChEMBL | Inhibition of bovine kidney LMW-PTPase using phosphotyrosine substrate | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2012) 55: 2-22 [PMID:21988196] |
| Pancreatic triacylglycerol lipase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1687677] [UniProtKB: P00591] | ||||||||
| ChEMBL | Inhibition of porcine pancreatic lipase pre-incubated for 15 mins before p-nitrophenylbutyrate substrate addition by microplate reader based method | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3455-3457 [PMID:26227773] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 4.79 | pIC50 | 16100 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Protein E6 in Human papillomavirus type 16 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010633] [UniProtKB: P03126] | ||||||||
| ChEMBL | Inhibition of GST-tagged Human papillomavirus 16 protein E6 interaction with His-tagged human caspase 8 expressed in Escherichia coli after 1 hr incubation followed by overnight incubation by Alpha screening technique | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2125-2129 [PMID:22300659] |
| RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332] | ||||||||
| ChEMBL | Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis | B | 5.37 | pIC50 | 4300 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 87-93 [PMID:26602279] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Inhibition of PIM1 kinase | B | 0.43 | pIC50 | -0.43 | uM | -Log IC50 | Bioorg Med Chem (2007) 15: 6463-6473 [PMID:17637507] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Inhibition of PLK1 | B | 4.9 | pIC50 | 12600 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4972-4977 [PMID:18762425] |
| Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37] | ||||||||
| ChEMBL | Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay | B | 5.24 | pKi | 5740 | nM | Ki | Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024] |
| ChEMBL | Inhibition of human URAT1-mediated urate uptake in HEK293 cells | B | 5.7 | pIC50 | 2000 | nM | IC50 | Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024] |
| Urate anion exchanger 1/Solute carrier family 22 member 12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075239] [GtoPdb: 1031] [UniProtKB: Q3ZAV1] | ||||||||
| ChEMBL | Inhibition of human URAT1-mediated urate uptake in rat renal brush border membrane vesicles | B | 4.74 | pIC50 | 18000 | nM | IC50 | Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024] |
| Sortase A in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5362] [UniProtKB: Q9S446] | ||||||||
| ChEMBL | Inhibition of 6-His tagged Staphylococcus aureus recombinant sortase delta N24 expressed in Escherichia coli BL21 (DE3) | B | 4.43 | pIC50 | 37390 | nM | IC50 | Bioorg Med Chem (2009) 17: 2886-2893 [PMID:19269184] |
| ChEMBL | Inhibition of Staphylococcus aureus Newman recombinant SrtA expressed in Escherichia coli cells using Dabcyl-QALPETGEE-Edans as substrate by fluorimetric analysis | B | 4.43 | pIC50 | 37390 | nM | IC50 | Bioorg Med Chem (2019) 27: 115043-115043 [PMID:31420255] |
| ChEMBL | Inhibition of recombinant Staphylococcus aureus wild type truncated C-terminal His6 tagged Srt A using Abz-Leu-Pro-Glu-Thr-Gly-Lys(Dnp)-NH2 as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by FRET assay in presence of 0.5 mM reducing agent, DTT | B | 4.72 | pIC50 | 19000 | nM | IC50 | Bioorg Med Chem (2019) 27: 115043-115043 [PMID:31420255] |
| Sortase A in Streptococcus mutans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523939] [UniProtKB: Q8CM62] | ||||||||
| ChEMBL | Binding affinity to Streptococcus mutans Sortase A | B | 4.57 | pIC50 | 27200 | nM | IC50 | Medchemcomm (2019) 10: 1057-1067 [PMID:31391878] |
| tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] | ||||||||
| ChEMBL | Displacement of [3H]colchicine from tubulin (unknown origin) | B | 4 | pKd | >100000 | nM | Kd | J Med Chem (2013) 56: 7382-7395 [PMID:23961916] |
| spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| ChEMBL | Inhibition of SYK | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2012) 55: 3614-3643 [PMID:22257213] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Inhibition of YES (unknown origin) | B | 5.1 | pKi | 7900 | nM | Ki | Eur J Med Chem (2019) 166: 186-196 [PMID:30769179] |
| xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] | ||||||||
| ChEMBL | Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | B | 5 | pIC50 | 10100 | nM | IC50 | J Nat Prod (1998) 61: 71-76 [PMID:9461655] |
| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
