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SET domain containing 7, histone lysine methyltransferase

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Target id: 2703

Nomenclature: SET domain containing 7, histone lysine methyltransferase

Family: 2.1.1.43 Histone methyltransferases (HMTs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 366 4q31.1 SETD7 SET domain containing 7, histone lysine methyltransferase
Mouse - 366 3 C Setd7 SET domain containing (lysine methyltransferase) 7
Rat - 366 2q26 Setd7 SET domain containing 7, histone lysine methyltransferase
Previous and Unofficial Names Click here for help
KMT7 | SET7/9 | SET domain containing (lysine methyltransferase) 7 | SET domain containing lysine methyltransferase 7 | SET domain containing 7
Database Links Click here for help
Alphafold Q8WTS6 (Hs), Q8VHL1 (Mm)
BRENDA 2.1.1.43
ChEMBL Target CHEMBL5523 (Hs)
Ensembl Gene ENSG00000145391 (Hs), ENSMUSG00000037111 (Mm), ENSRNOG00000013045 (Rn)
Entrez Gene 80854 (Hs), 73251 (Mm), 689954 (Rn)
Human Protein Atlas ENSG00000145391 (Hs)
KEGG Enzyme 2.1.1.43
KEGG Gene hsa:80854 (Hs), mmu:73251 (Mm), rno:689954 (Rn)
OMIM 606594 (Hs)
Pharos Q8WTS6 (Hs)
RefSeq Nucleotide NM_030648 (Hs), NM_080793 (Mm), NM_001109558 (Rn)
RefSeq Protein NP_085151 (Hs), NP_542983 (Mm), NP_001103028 (Rn)
SynPHARM 81848 (in complex with (R)-PFI-2)
UniProtKB Q8WTS6 (Hs), Q8VHL1 (Mm)
Wikipedia SETD7 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.1.1.43

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(R)-PFI-2 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 9.5 pKi 1
⤷ pKi 9.5 (Ki 3.3x10-10 M) [1]

References

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1. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA et al.. (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci USA, 111 (35): 12853-8. [PMID:25136132]

How to cite this page

2.1.1.43 Histone methyltransferases (HMTs): SET domain containing 7, histone lysine methyltransferase. Last modified on 27/03/2019. Accessed on 04/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2703.