ChEMBL ligand: CHEMBL509456
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271] There should be some charts here, you may need to enable JavaScript!
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75] There should be some charts here, you may need to enable JavaScript!
P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] There should be some charts here, you may need to enable JavaScript!
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells	F	5.01	pIC50	9830	nM	IC50	Mol Pharmacol (2001) 59: 1077-1085 [PMID:11306690]
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb	-	-	7.8	pKi	-	-	-	Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb	-	-	6.97	pIC50	107	nM	IC50	Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb	-	-	6.41	pEC50	391	nM	EC50	Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb	-	-	6.67	pEC50	212	nM	EC50	Nature (1999) 399: 789-93 [PMID:10391245]
ChEMBL	Agonist activity at human CysLT1 receptor	F	6.98	pEC50	104	nM	EC50	J Med Chem (2021) 64: 16512-16529 [PMID:34767347]
GtoPdb	-	-	7.24	pEC50	58	nM	EC50	Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]; Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb	-	-	6.5	pKi	-	-	-	Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb	-	-	5.72	pIC50	1890	nM	IC50	Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]
GtoPdb	-	-	6.16	pIC50	693	nM	IC50	J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb	-	-	5.92	pEC50	1208	nM	EC50	J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
ChEMBL	Agonist activity at human CysLT2 receptor	F	6.53	pEC50	293	nM	EC50	J Med Chem (2021) 64: 16512-16529 [PMID:34767347]
GtoPdb	-	-	7.11	pEC50	77	nM	EC50	Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL	Agonist activity at human P2Y12 receptor	F	8.89	pEC50	1.3	nM	EC50	J Med Chem (2009) 52: 5803-5815 [PMID:19739647]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb	-	-	9.51	pEC50	0.31	nM	EC50	PLoS ONE (2008) 3: e3579 [PMID:18974869]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]