oleanolic acid [Ligand Id: 3306] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL168 (NSC-114945) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3393] [GtoPdb: 2435] [UniProtKB: P17764] | ||||||||
| ChEMBL | Inhibition of rat liver microsomal ACAT | B | 4.11 | pIC50 | 77900 | nM | IC50 | Eur J Med Chem (2017) 139: 201-213 [PMID:28802120] |
| carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141] | ||||||||
| ChEMBL | Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by fluorescence assay | B | 7 | pIC50 | 100 | nM | IC50 | J Nat Prod (2020) 83: 2940-2949 [PMID:32951423] |
| Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
| ChEMBL | Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 W220Y mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation | B | 5.45 | pKi | 3560 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 V301L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation | B | 6.03 | pKi | 940 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 Q303S mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation | B | 6.18 | pKi | 660 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 K125L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation | B | 6.8 | pKi | 160 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation | B | 7.14 | pKi | 72 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated for 2 hrs before [1-14C]farnesol challenge measured after 6 hrs | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| ChEMBL | Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction | B | 7.05 | pIC50 | 90 | nM | IC50 | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] | ||||||||
| ChEMBL | Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs using factor 10a chromogenic substrate in presence of prothrombin complex | B | 8.3 | pIC50 | 4.97 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1026-1030 [PMID:28109788] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Nat Prod (2019) 82: 3311-3320 [PMID:31774676] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX2 by scintillation proximity assay | B | 4.06 | pIC50 | 87000 | nM | IC50 | J Nat Prod (2002) 65: 1517-1521 [PMID:12444669] |
| ChEMBL | Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis | B | 4.4 | pIC50 | >40000 | nM | IC50 | J Nat Prod (2019) 82: 3311-3320 [PMID:31774676] |
| DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746] | ||||||||
| ChEMBL | Inhibition of lyase activity of DNA polymerase beta | B | 4.58 | pIC50 | 26250 | nM | IC50 | Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122] |
| ChEMBL | Inhibition of polymerase activity of DNA polymerase beta | B | 4.6 | pIC50 | 24980 | nM | IC50 | Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122] |
| ChEMBL | Inhibition of DNA polymerase beta lyase activity | B | 5.06 | pIC50 | 8800 | nM | IC50 | J Nat Prod (2004) 67: 964-967 [PMID:15217274] |
| ChEMBL | Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay | B | 5.06 | pIC50 | 8800 | nM | IC50 | J Nat Prod (2003) 66: 1463-1465 [PMID:14640519] |
| ChEMBL | Inhibition of DNA polymerase beta | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| GtoPdb | Inhibition of POLB polymerase activity | - | 5.6 | pIC50 | 2498 | nM | IC50 | Bioorg Med Chem (2008) 16: 4331-40 [PMID:18343122] |
| DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766] | ||||||||
| ChEMBL | Inhibition of rat DNA polymerase beta in presence of BSA | B | 5.12 | pIC50 | 7500 | nM | IC50 | J Nat Prod (1999) 62: 1624-1626 [PMID:10654412] |
| ChEMBL | Inhibition of rat DNA polymerase beta in absence of BSA | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Nat Prod (1999) 62: 1624-1626 [PMID:10654412] |
| Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305] | ||||||||
| ChEMBL | Inhibition of CDC25B (unknown origin) using pNPP as substrate by spectrophotometry | B | 6.01 | pIC50 | 980 | nM | IC50 | Bioorg Med Chem (2015) 23: 38-45 [PMID:25497963] |
| Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
| ChEMBL | Inhibition of human VHR expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins | B | 5.27 | pIC50 | 5400 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Nat Prod (2019) 82: 3065-3073 [PMID:31718182] |
| ChEMBL | Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Nat Prod (2019) 82: 3065-3073 [PMID:31718182] |
| ChEMBL | Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Nat Prod (2019) 82: 3065-3073 [PMID:31718182] |
| Glycogen phosphorylase, muscle form in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4696] [UniProtKB: P00489] | ||||||||
| ChEMBL | Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green staining | B | 4.64 | pIC50 | 22900 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1036-1039 [PMID:22204907] |
| ChEMBL | Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 mins | B | 4.66 | pIC50 | 22100 | nM | IC50 | J Nat Prod (2009) 72: 1414-1418 [PMID:19642687] |
| ChEMBL | Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method | B | 4.85 | pIC50 | 14125.38 | nM | IC50 | Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694] |
| ChEMBL | Inhibition of rabbit muscle GPa | B | 4.85 | pIC50 | 14000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2915-2919 [PMID:16546381] |
| ChEMBL | Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2008) 51: 3540-3554 [PMID:18517260] |
| ChEMBL | Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method | B | 4.85 | pIC50 | 14000 | nM | IC50 | Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694] |
| GP41 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270] | ||||||||
| ChEMBL | Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay | B | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2014) 57: 7342-7354 [PMID:25156906] |
| GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
| ChEMBL | Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay | F | 5.65 | pEC50 | 2250 | nM | EC50 | J Med Chem (2010) 53: 178-190 [PMID:19911773] |
| GtoPdb | - | - | 5.65 | pEC50 | 2250 | nM | EC50 | Biochem Biophys Res Commun (2007) 362: 793-8 [PMID:17825251] |
| Hemagglutinin in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559640] [UniProtKB: B4URE7] | ||||||||
| ChEMBL | Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assay | B | 4.96 | pKd | 10900 | nM | Kd | J Med Chem (2022) 65: 7154-7169 [PMID:35579113] |
| RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
| ChEMBL | Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419] |
| Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666] | ||||||||
| ChEMBL | Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr | B | 4.64 | pIC50 | 22900 | nM | IC50 | Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996] |
| ChEMBL | Inhibition of human LMW-PTP IF2 using p-nitrophenylphosphate as substrate by spectrophotometry | B | 4.64 | pIC50 | 22900 | nM | IC50 | Eur J Med Chem (2014) 87: 316-327 [PMID:25264584] |
| ChEMBL | Inhibition of human recombinant LMW-PTP1 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr | B | 4.67 | pIC50 | 21200 | nM | IC50 | Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996] |
| ChEMBL | Inhibition of human LMW-PTP IF1 using p-nitrophenylphosphate as substrate by spectrophotometry | B | 4.67 | pIC50 | 21200 | nM | IC50 | Eur J Med Chem (2014) 87: 316-327 [PMID:25264584] |
| sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8] | ||||||||
| ChEMBL | Inhibition of SIRT5 (unknown origin) | B | 4.15 | pIC50 | 70000 | nM | IC50 | Eur J Med Chem (2022) 236: 114363-114363 [PMID:35436671] |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Inhibition of inducible nitric oxide synthase in activated macrophages | B | 4.4 | pIC50 | >40000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2215-2219 [PMID:15837296] |
| nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236] | ||||||||
| ChEMBL | Activation of Nrf2 (unknown origin) expressed in human HaCaT-ARE-luc cells after 6 hrs by luciferase reporter gene assay | B | 4.72 | pEC50 | >=18900 | nM | EC50 | J Nat Prod (2017) 80: 2276-2283 [PMID:28753294] |
| RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [GtoPdb: 3280] [UniProtKB: Q04206] | ||||||||
| ChEMBL | Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2018) 26: 4452-4460 [PMID:30057155] |
| Pancreatic alpha-amylase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5730] [UniProtKB: P00690] | ||||||||
| ChEMBL | Non-competitive inhibition of porcine pancreatic alpha-amylase assessed as inhibitor-enzyme complex using starch as substrate by Lineweaver-Burk plot analysis | B | 4.02 | pKi | 95.8 | uM | Kii | Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635] |
| ChEMBL | Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by dinitrosalicylic acid reagent based assay | B | 4.03 | pIC50 | 94100 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635] |
| sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054] | ||||||||
| ChEMBL | Inhibition of phospholipase A2 | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
| Phosphotyrosine protein phosphatase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295521] [UniProtKB: A0A045ISB3] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric analysis | B | 4.66 | pIC50 | 22100 | nM | IC50 | J Nat Prod (2018) 81: 1376-1383 [PMID:29792702] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measured for 5 mins by spectrophotometric analysis | B | 4.66 | pIC50 | 22000 | nM | IC50 | J Nat Prod (2019) 82: 2268-2278 [PMID:31365251] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis H37Rv ptpB expressed in Escherichia coli BL21 (DH3) cells using 6,8-difluoromethylumbelliferyl phosphate as substrate incubated for 30 mins by fluorescence based assay | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Nat Prod (2019) 82: 3440-3449 [PMID:31799843] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 | F | 4.58 | pIC50 | 26240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 | F | 4.62 | pIC50 | 23810 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058] |
| Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] | ||||||||
| ChEMBL | Inhibition of HIV1 recombinant protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 as substrate by FRET assay | B | 4.24 | pIC50 | 57700 | nM | IC50 | Eur J Med Chem (2014) 74: 278-301 [PMID:24480359] |
| ChEMBL | Inhibition of HIV1 protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 peptide as substrate by FRET assay | B | 4.24 | pIC50 | 57700 | nM | IC50 | J Nat Prod (2019) 82: 2886-2896 [PMID:31617361] |
| ChEMBL | Inhibition of HIV1 protease activity | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2009) 17: 5238-5246 [PMID:19515569] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate | B | 5.22 | pKi | 6000 | nM | Ki | Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996] |
| ChEMBL | Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot method | B | 5.22 | pKi | 6000 | nM | Ki | Eur J Med Chem (2014) 87: 316-327 [PMID:25264584] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISA | B | 4.39 | pIC50 | 40700 | nM | IC50 | J Nat Prod (2019) 82: 3267-3278 [PMID:31738062] |
| ChEMBL | Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr | B | 5.02 | pIC50 | 9500 | nM | IC50 | Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996] |
| ChEMBL | Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometry | B | 5.02 | pIC50 | 9500 | nM | IC50 | Eur J Med Chem (2014) 87: 316-327 [PMID:25264584] |
| ChEMBL | Inhibition of human recombinant PTP1B after 30 mins | B | 5.12 | pIC50 | 7600 | nM | IC50 | J Nat Prod (2008) 71: 1775-1778 [PMID:18798681] |
| ChEMBL | Inhibition of GST-tagged human recombinant PTP1B using para-nitrophenyl phosphate as substrate by spectrophotometric analysis | B | 5.25 | pIC50 | 5600 | nM | IC50 | J Nat Prod (2012) 75: 1160-1166 [PMID:22690646] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.3 | pIC50 | 5050.1 | nM | IC50 | Med Chem Res (2012) 21: 351-361 |
| ChEMBL | Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition and measured every 5 mins for 30 mins | B | 5.37 | pIC50 | 4300 | nM | IC50 | J Nat Prod (2019) 82: 2916-2924 [PMID:31618031] |
| ChEMBL | Inhibition of GST-tagged human PTP1B | B | 5.38 | pIC50 | 4200 | nM | IC50 | J Nat Prod (2009) 72: 1620-1626 [PMID:19702283] |
| ChEMBL | Inhibition of human recombinant PTP1B | B | 5.41 | pIC50 | 3900 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3273-3276 [PMID:16580200] |
| ChEMBL | Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric analysis | B | 5.42 | pIC50 | 3840 | nM | IC50 | J Nat Prod (2011) 74: 2431-2437 [PMID:22044245] |
| ChEMBL | Inhibition of recombinant human PTP1B catalytic domain expressed in Escherichia coli BL21-CodonPlus (DE3) using pNPP as substrate measured for 2 mins | B | 5.46 | pIC50 | 3480 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1105-1108 [PMID:28111140] |
| ChEMBL | Inhibition of PTP1B by pNPP assay | B | 5.47 | pIC50 | 3370 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.47 | pIC50 | 3370 | nM | IC50 | Med Chem Res (2012) 21: 351-361 |
| ChEMBL | Inhibition of recombinant human GST-tagged PTP1B catalytic domain expressed in Escherichia coli BL21 using para-nitrophenyl phosphate as substrate | B | 5.48 | pIC50 | 3320 | nM | IC50 | J Nat Prod (2017) 80: 2874-2882 [PMID:29064696] |
| ChEMBL | Inhibition of human PTP1B | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126943-126943 [PMID:31924496] |
| ChEMBL | Inhibition of recombinant human PTP1B catalytic domain assessed as hydrolysis of pNPP after 2 mins | B | 5.52 | pIC50 | 3020 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 778-781 [PMID:26774579] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.52 | pIC50 | 3020 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 2211-2216 [PMID:25872983] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.52 | pIC50 | 3020 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5061-5065 [PMID:23942421] |
| ChEMBL | Inhibition of purified recombinant PTP1B catalytic domain (unknown origin) using pNPP as substrate by spectrophotometry | B | 5.52 | pIC50 | 3020 | nM | IC50 | Bioorg Med Chem (2015) 23: 38-45 [PMID:25497963] |
| ChEMBL | Inhibition of PTP1B (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultilable plate reader based method | B | 5.53 | pIC50 | 2960 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2358-2363 [PMID:31221555] |
| ChEMBL | Inhibition of PTP1B (unknown origin) by SpectraMax 340 microplate reader Analysis | B | 5.53 | pIC50 | 2950 | nM | IC50 | Eur J Med Chem (2021) 221: 113511-113511 [PMID:34000484] |
| ChEMBL | Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric analysis | B | 5.57 | pIC50 | 2690 | nM | IC50 | Eur J Med Chem (2019) 172: 163-173 [PMID:30978561] |
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate relative to control | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Nat Prod (2024) 87: 121-131 [PMID:38151459] |
| ChEMBL | Inhibition of human PTP1B | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1334-1337 [PMID:23357636] |
| ChEMBL | Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5154-5157 [PMID:29100798] |
| ChEMBL | Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127170-127170 [PMID:32273218] |
| ChEMBL | Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based analysis | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Nat Prod (2021) 84: 2303-2311 [PMID:34279099] |
| ChEMBL | Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substrate measured continuously for 3 mins by colorimetric method | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Nat Prod (2018) 81: 1810-1818 [PMID:30067363] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate after 3 mins by colorimetric analysis | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Nat Prod (2016) 79: 1365-1372 [PMID:27142786] |
| ChEMBL | Inhibition of recombinant human PTP1B using pNNP as substrate after 30 mins | B | 5.69 | pIC50 | 2058 | nM | IC50 | Eur J Med Chem (2018) 144: 692-700 [PMID:29289892] |
| ChEMBL | Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysis | B | 5.7 | pIC50 | 2010 | nM | IC50 | Eur J Med Chem (2013) 69: 399-412 [PMID:24090912] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate measured after 30 mins | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2017) 80: 2509-2514 [PMID:28834433] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1889-1894 [PMID:24684845] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate | B | 5.79 | pIC50 | 1620 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1187-1193 [PMID:30910462] |
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins | B | 5.81 | pIC50 | 1536 | nM | IC50 | Bioorg Med Chem (2015) 23: 7079-7088 [PMID:26481657] |
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) assessed as pNPP hydrolysis after 30 mins | B | 5.81 | pIC50 | 1536 | nM | IC50 | Bioorg Med Chem (2015) 23: 4891-4898 [PMID:26100442] |
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins | B | 5.81 | pIC50 | 1536 | nM | IC50 | Eur J Med Chem (2016) 118: 27-33 [PMID:27123900] |
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate reader analysis | B | 5.93 | pIC50 | 1170 | nM | IC50 | Bioorg Med Chem (2015) 23: 797-802 [PMID:25600405] |
| ChEMBL | Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2151-2154 [PMID:23434422] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 5.99 | pIC50 | 1030 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 904-907 [PMID:25595683] |
| ChEMBL | Inhibition of human recombinant PTP1B using pNPP as substrate assessed as rate of hydrolysis incubated for 10 mins prior to substrate addition measured after 30 mins by microplate reader analysis | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2015) 78: 1428-1433 [PMID:26083682] |
| ChEMBL | Inhibition of PTP1B (unknown origin) by DAS-ELISA | B | 6 | pIC50 | 990 | nM | IC50 | Bioorg Med Chem (2023) 83: 117240-117240 [PMID:36963270] |
| ChEMBL | Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate reader analysis | B | 6.14 | pIC50 | 730 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 315-317 [PMID:26711144] |
| ChEMBL | Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substrate addition | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3900-3902 [PMID:26253631] |
| ChEMBL | Inhibition of PTP1B (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3087-3090 [PMID:26115570] |
| ChEMBL | Inhibition of human recombinant PTP1B using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance based analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2021) 53: 128422-128422 [PMID:34710624] |
| Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350] | ||||||||
| ChEMBL | Inhibition of human recombinant SHP1 | B | 4.5 | pIC50 | 31330 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| ChEMBL | Inhibition of human SHP1 using pNPP as substrate incubated for 30 mins | B | 4.85 | pIC50 | 14190 | nM | IC50 | Eur J Med Chem (2016) 118: 27-33 [PMID:27123900] |
| protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Inhibition of human SHP2 using pNPP as substrate incubated for 30 mins | B | 4.93 | pIC50 | 11620 | nM | IC50 | Eur J Med Chem (2016) 118: 27-33 [PMID:27123900] |
| RTP Type A/Receptor-type tyrosine-protein phosphatase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3918] [GtoPdb: 1850] [UniProtKB: P18433] | ||||||||
| ChEMBL | Inhibition of human recombinant PTPalpha | B | 4.4 | pIC50 | >40000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] | ||||||||
| ChEMBL | Inhibition of human recombinant PTPepsilon | B | 4.4 | pIC50 | >40000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| RTP Type F/Receptor-type tyrosine-protein phosphatase F (LAR) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3521] [GtoPdb: 1855] [UniProtKB: P10586] | ||||||||
| ChEMBL | Inhibition of human recombinant LAR | B | 4.4 | pIC50 | >40000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| ChEMBL | Inhibition of human LAR using pNPP as substrate incubated for 30 mins | B | 4.65 | pIC50 | 22310 | nM | IC50 | Eur J Med Chem (2016) 118: 27-33 [PMID:27123900] |
| ChEMBL | Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr | B | 4.93 | pIC50 | 11800 | nM | IC50 | Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996] |
| signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
| ChEMBL | Inhibition of IFN-gamma stimulated STAT3 (unknown origin) expressed in human HeLa cells after 6 hrs by luciferase reporter gene assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2017) 80: 2276-2283 [PMID:28753294] |
| protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
| ChEMBL | Inhibition of TCPTP (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultilable plate reader based method | B | 4.98 | pIC50 | 10550 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2358-2363 [PMID:31221555] |
| ChEMBL | Inhibition of GST-tagged human TCPCP expressed in Escherichia coli using pNPP as substrate | B | 5.1 | pIC50 | 7860 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1105-1108 [PMID:28111140] |
| ChEMBL | Inhibition of human recombinant GST-tagged TCPTP (catalytic domain 41 to 1075 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric analysis | B | 5.19 | pIC50 | 6420 | nM | IC50 | Eur J Med Chem (2019) 172: 163-173 [PMID:30978561] |
| ChEMBL | Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins | B | 5.26 | pIC50 | 5460 | nM | IC50 | Bioorg Med Chem (2015) 23: 7079-7088 [PMID:26481657] |
| ChEMBL | Inhibition of human TCPTP using pNPP as substrate incubated for 30 mins | B | 5.26 | pIC50 | 5460 | nM | IC50 | Eur J Med Chem (2016) 118: 27-33 [PMID:27123900] |
| ChEMBL | Inhibition of TCPTP (unknown origin) assessed as pNPP hydrolysis after 30 mins | B | 5.26 | pIC50 | 5460 | nM | IC50 | Bioorg Med Chem (2015) 23: 4891-4898 [PMID:26100442] |
| ChEMBL | Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127170-127170 [PMID:32273218] |
| ChEMBL | Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5154-5157 [PMID:29100798] |
| ChEMBL | Inhibition of TCPTP (unknown origin) using pNPP as substrate | B | 5.31 | pIC50 | 4890 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1187-1193 [PMID:30910462] |
| ChEMBL | Inhibition of TC-PTP (unknown origin) using pNPP as substrate by spectrophotometry | B | 5.35 | pIC50 | 4440 | nM | IC50 | Bioorg Med Chem (2015) 23: 38-45 [PMID:25497963] |
| ChEMBL | Inhibition of TCPTP (unknown origin) using pNPP as substrate | B | 5.37 | pIC50 | 4230 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1889-1894 [PMID:24684845] |
| ChEMBL | Inhibition of TCPTP by pNPP assay | B | 5.47 | pIC50 | 3400 | nM | IC50 | Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891] |
| ChEMBL | Inhibition of TCPTP (unknown origin) by SpectraMax 340 microplate reader Analysis | B | 5.53 | pIC50 | 2950 | nM | IC50 | Eur J Med Chem (2021) 221: 113511-113511 [PMID:34000484] |
| ChEMBL | Inhibition of full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419] |
| ChEMBL | Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance based analysis | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2021) 53: 128422-128422 [PMID:34710624] |
| Ubiquitin carboxyl-terminal hydrolase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157850] [UniProtKB: Q93009] | ||||||||
| ChEMBL | Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by coomassie brilliant blue staining-based SDS-PAGE analysis | B | 4.9 | pIC50 | 12500 | nM | IC50 | Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
