apomorphine [Ligand Id: 33] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL53 (6a.beta.-aporphine-10,11-diol, APL-130277, Apomorphine, Apomorphinum, VR-040, VR040) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells | B | 6.17 | pKd | 680 | nM | Kd | J Med Chem (1996) 39: 850-859 [PMID:8632409] |
| ChEMBL | Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells | B | 6.18 | pKi | 660 | nM | Ki | Eur J Med Chem (2012) 55: 255-261 [PMID:22846798] |
| ChEMBL | Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assay | B | 6.19 | pKi | 650 | nM | Ki | ACS Med Chem Lett (2011) 2: 189-194 [PMID:21666830] |
| GtoPdb | - | - | 6.2 | pKi | - | - | - |
Nature (1991) 350: 614-9 [PMID:1826762]; J Biol Chem (1994) 269: 27925-31 [PMID:7525564] |
| ChEMBL | Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis | B | 6.31 | pKi | 492 | nM | Ki | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
| ChEMBL | Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay | B | 6.43 | pKi | 372 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127053-127053 [PMID:32107165] |
| ChEMBL | Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells | B | 6.54 | pKi | 290 | nM | Ki | Bioorg Med Chem (2008) 16: 6675-6681 [PMID:18562201] |
| ChEMBL | Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter | B | 7.14 | pKi | 72 | nM | Ki | Eur J Med Chem (2011) 46: 2992-2999 [PMID:21550699] |
| ChEMBL | Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2009) 17: 4756-4762 [PMID:19454369] |
| ChEMBL | Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assay | B | 8.34 | pKi | 4.6 | nM | Ki | ACS Med Chem Lett (2011) 2: 189-194 [PMID:21666830] |
| ChEMBL | Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay | B | 6.28 | pEC50 | 520.8 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay | B | 6.3 | pEC50 | 501.19 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production | F | 7.28 | pEC50 | 52 | nM | EC50 | Bioorg Med Chem (2008) 16: 3438-3444 [PMID:18313303] |
| ChEMBL | Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins | F | 7.59 | pEC50 | 25.7 | nM | EC50 | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
| ChEMBL | Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay | F | 8.4 | pEC50 | 3.98 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay | F | 8.42 | pEC50 | 3.77 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616] | ||||||||
| ChEMBL | Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells | B | 7 | pKi | 101 | nM | Ki | Bioorg Med Chem (2008) 16: 4563-4568 [PMID:18313931] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum | B | 6 | pKi | 1010 | nM | Ki | J Med Chem (2008) 51: 983-987 [PMID:18251489] |
| ChEMBL | In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate | B | 6.05 | pKi | 888 | nM | Ki | J Med Chem (1989) 32: 1431-1435 [PMID:2525621] |
| ChEMBL | In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1 | B | 6.63 | pKi | 236 | nM | Ki | J Med Chem (1996) 39: 3503-3513 [PMID:8784448] |
| ChEMBL | In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement. | B | 6.63 | pKi | 236 | nM | Ki | J Med Chem (1996) 39: 3491-3502 [PMID:8784447] |
| ChEMBL | Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1 | B | 6.63 | pKi | 236 | nM | Ki | J Med Chem (1995) 38: 647-658 [PMID:7861413] |
| ChEMBL | Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand | B | 6.63 | pKi | 236 | nM | Ki | J Med Chem (1990) 33: 1800-1805 [PMID:1971309] |
| ChEMBL | Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand | B | 6.66 | pKi | >221 | nM | Ki | J Med Chem (1994) 37: 3523-3533 [PMID:7932581] |
| ChEMBL | Displacement of [3H]SCH-23390 from rat dopamine D1 receptor | B | 6.68 | pKi | 210 | nM | Ki | J Med Chem (2007) 50: 171-181 [PMID:17228858] |
| ChEMBL | Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand. | B | 6.74 | pKi | 181.97 | nM | Ki | J Med Chem (2000) 43: 599-608 [PMID:10691686] |
| ChEMBL | Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes | B | 7.28 | pKi | 53 | nM | Ki | J Med Chem (1986) 29: 1904-1912 [PMID:3761310] |
| ChEMBL | Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (1990) 33: 2408-2412 [PMID:1975274] |
| ChEMBL | Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane | B | 6.35 | pIC50 | 444 | nM | IC50 | J Med Chem (1990) 33: 3122-3124 [PMID:2147956] |
| ChEMBL | In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement. | B | 6.36 | pIC50 | 432 | nM | IC50 | J Med Chem (1990) 33: 600-607 [PMID:2405158] |
| ChEMBL | Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes | B | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 883-886 [PMID:11294383] |
| ChEMBL | Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined | B | 6.42 | pIC50 | 384 | nM | IC50 | J Med Chem (1990) 33: 311-317 [PMID:1967314] |
| ChEMBL | In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390 | B | 6.42 | pIC50 | 384 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 539-544 |
| ChEMBL | Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand. | F | 6.42 | pIC50 | 384 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 189-192 |
| ChEMBL | Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand | B | 6.42 | pIC50 | 384 | nM | IC50 | J Med Chem (1991) 34: 2736-2746 [PMID:1680195] |
| ChEMBL | In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1 | B | 6.62 | pIC50 | 238 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 639-644 |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Compound was evaluated for the ability to displace [3H]spiperone at Dopamine receptor D2 in porcine anterior pituitary gland as low affinity state | B | 6.9 | pKd | 127 | nM | Kd | J Med Chem (1989) 32: 1198-1201 [PMID:2524592] |
| ChEMBL | Equilibrium dissociation constant against recombinant Dopamine receptor D2A expressed in COS7 cells | B | 7.62 | pKd | 24 | nM | Kd | J Med Chem (1996) 39: 850-859 [PMID:8632409] |
| ChEMBL | Compound was evaluated for the ability to displace [3H]spiperone at Dopamine receptor D2 in porcine anterior pituitary gland as high affinity state | B | 9.18 | pKd | 0.66 | nM | Kd | J Med Chem (1989) 32: 1198-1201 [PMID:2524592] |
| ChEMBL | Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells | B | 6.61 | pKi | 244 | nM | Ki | J Med Chem (2010) 53: 2510-2520 [PMID:20155917] |
| ChEMBL | Tested for affinity against cloned mammalian dopamine autoreceptor (DA) D2 receptors expressed in CHO-K1 cells using [3H]spiperone as radioligand | B | 6.66 | pKi | >217 | nM | Ki | J Med Chem (1994) 37: 2735-2753 [PMID:8064801] |
| ChEMBL | Displacement of [3H]spiperone from human dopamine D2 receptor expressed in HEK293 cells | B | 7.01 | pKi | 98 | nM | Ki | Bioorg Med Chem (2008) 16: 6675-6681 [PMID:18562201] |
| ChEMBL | Displacement of [125I]iodosulpride from human D2 receptor expressed in CHO cells incubated for 40 mins by radio ligand binding assay | B | 7.09 | pKi | 82 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127053-127053 [PMID:32107165] |
| ChEMBL | Displacement of [3H]raclopride from human dopamine D2L receptor expressed in HEK293 cells by scintillation counting analysis | B | 7.28 | pKi | 53 | nM | Ki | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
| ChEMBL | Displacement of [3H]raclopride from human D2L receptor expressed in HEK293 cells | B | 7.3 | pKi | 50 | nM | Ki | Eur J Med Chem (2012) 55: 255-261 [PMID:22846798] |
| ChEMBL | Displacement of [3H]-raclopride from recombinant human D2 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis | B | 7.38 | pKi | 42 | nM | Ki | Eur J Med Chem (2019) 166: 144-158 [PMID:30703658] |
| ChEMBL | Displacement of [3H]-raclopride from human D2 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method | B | 7.38 | pKi | 42 | nM | Ki | Eur J Med Chem (2019) 180: 383-397 [PMID:31325785] |
| ChEMBL | In vitro affinity at human cloned Dopamine receptor D2A by [3H]-raclopride displacement. | B | 7.38 | pKi | 41.9 | nM | Ki | J Med Chem (1996) 39: 3491-3502 [PMID:8784447] |
| ChEMBL | Displacement of [3H]raclopride from human dopamine receptor D2A expressed in mouse Ltk cells | B | 7.38 | pKi | 41.9 | nM | Ki | J Med Chem (2001) 44: 1337-1340 [PMID:11311055] |
| ChEMBL | Displacement of [3H]raclopride from human Dopamine receptor D2A | B | 7.38 | pKi | 41.9 | nM | Ki | J Med Chem (1996) 39: 3503-3513 [PMID:8784448] |
| ChEMBL | Ability to displace [3H]raclopride binding to cloned human Dopamine receptor D2A | B | 7.38 | pKi | 41.9 | nM | Ki | J Med Chem (1995) 38: 647-658 [PMID:7861413] |
| ChEMBL | In vitro binding affinity towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand. | B | 7.38 | pKi | 41.6 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 367-370 [PMID:11212112] |
| ChEMBL | Binding affinity was measured on cloned Human D2A Receptor which is labeled by [3H]raclopride | B | 7.38 | pKi | 41.6 | nM | Ki | J Med Chem (2000) 43: 1339-1349 [PMID:10753471] |
| ChEMBL | Displacement of [3H]raclopride from human cloned dopamine D2 receptor expressed in CHO cell membrane | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem (2008) 16: 4563-4568 [PMID:18313931] |
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]; J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Neuroreport (1995) 6: 329-332 [PMID:7756621]; Neuropsychopharmacology (1995) 12: 335-45 [PMID:7576010]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163] |
| ChEMBL | Tested for binding affinity towards human D2L receptor using [3H]spiperone as radioligand | B | 7.55 | pKi | 28 | nM | Ki | J Med Chem (1994) 37: 3523-3533 [PMID:7932581] |
| ChEMBL | Compound was evaluated for the binding affinity against [3H]U-86,170-labeled D2 sites in cloned CHO cells | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (1993) 36: 1069-1083 [PMID:8097538] |
| ChEMBL | Compound was evaluated for the binding affinity against [3H]U-86,170-labeled D2 sites in cloned CHO cells | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (1993) 36: 1053-1068 [PMID:8097537] |
| ChEMBL | Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membrane | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells | B | 9.21 | pKi | 0.62 | nM | Ki | J Med Chem (2010) 53: 2510-2520 [PMID:20155917] |
| ChEMBL | Displacement of [3H]spiperone from human recombinant dopamine D2L receptor expressed in CHOFlpIn cells after 3 hrs by liquid scintillation counting | B | 6.93 | pIC50 | 117 | nM | IC50 | Medchemcomm (2013) 4: 1290-1296 |
| ChEMBL | Agonist activity at human dopamine D2 receptor expressed in CHOK1 cells assessed as calcium mobilization by radiometric and luminescence plate counting method | F | 8.38 | pIC50 | 4.2 | nM | IC50 | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
| ChEMBL | Agonist activity at dopamine D2 receptor short isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay | B | 6.24 | pEC50 | 575.44 | nM | EC50 | US-20040213816-A1. Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases (2004) |
| ChEMBL | Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accumulation | F | 7.7 | pEC50 | 20 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 6691-6696 [PMID:17976986] |
| ChEMBL | Agonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay | F | 7.9 | pEC50 | 12.7 | nM | EC50 | Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027] |
| ChEMBL | Agonist activity at C-terminal RLuc8-fused D2 long receptor (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay | B | 8 | pEC50 | 10.1 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | Agonist activity at C-terminal RLuc8-fused D2 long receptor (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay | B | 8 | pEC50 | 10 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assay | B | 8.24 | pEC50 | 5.8 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | Agonist activity at human D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 8.24 | pEC50 | 5.8 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation after 15 mins | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
| ChEMBL | Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem (2008) 16: 3438-3444 [PMID:18313303] |
| ChEMBL | Agonist activity at ferret D2 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR | F | 8.74 | pEC50 | 1.8 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Agonist activity at human recombinant dopamine D2L receptor expressed in CHOFlpIn cells assessed as ERK1/2 phosphorylation by alphascreen assay | B | 8.77 | pEC50 | 1.7 | nM | EC50 | Medchemcomm (2013) 4: 1290-1296 |
| ChEMBL | Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay | F | 8.79 | pEC50 | 1.61 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| ChEMBL | Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay | F | 8.8 | pEC50 | 1.58 | nM | EC50 | ACS Med Chem Lett (2020) 11: 385-392 [PMID:32184974] |
| Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288] | ||||||||
| ChEMBL | Compound was tested for inhibition of [3H]spiroperidol binding against Dopamine receptor D2 | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (1986) 29: 1904-1912 [PMID:3761310] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. | B | 5.8 | pKd | 1600 | nM | Kd | J Med Chem (2000) 43: 3005-3019 [PMID:10956209] |
| ChEMBL | In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. | B | 5.92 | pKd | 1200 | nM | Kd | J Med Chem (2000) 43: 3005-3019 [PMID:10956209] |
| ChEMBL | In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes. | B | 6.22 | pKd | 600 | nM | Kd | J Med Chem (2000) 43: 3005-3019 [PMID:10956209] |
| ChEMBL | In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes. | B | 6.7 | pKd | 200 | nM | Kd | J Med Chem (2000) 43: 3005-3019 [PMID:10956209] |
| ChEMBL | Displacement of [3H]SCH23390 from dopamine D2 receptor low binding site in Sprague-Dawley rat striatum by scintillation counting | B | 7.01 | pKi | 98 | nM | Ki | ACS Med Chem Lett (2011) 2: 189-194 [PMID:21666830] |
| ChEMBL | Binding Affinity was determined against Dopamine receptor D2 in rat striatal membranes using [3H]- spiperone radioligand. | B | 7.26 | pKi | 54.95 | nM | Ki | J Med Chem (2000) 43: 599-608 [PMID:10691686] |
| ChEMBL | Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates. | B | 7.34 | pKi | 46 | nM | Ki | J Med Chem (1992) 35: 1076-1092 [PMID:1348089] |
| ChEMBL | Displacement of [3H]raclopride from rat dopamine D2(short) receptor expressed in CHOK1 cells | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem (2008) 16: 4563-4568 [PMID:18313931] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| ChEMBL | Tested for binding affinity towards rat striatal D2 receptor using [3H]spiperone as radioligand | B | 7.76 | pKi | 17.3 | nM | Ki | J Med Chem (1994) 37: 3523-3533 [PMID:7932581] |
| ChEMBL | Displacement of [3H]raclopride from rat dopamine D2 receptor | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2007) 50: 171-181 [PMID:17228858] |
| ChEMBL | Displacement of [3H]raclopride from rat D2 dopamine receptor expressed in CHOK1 cells after 90 mins by liquid scintillation counter scintillation counter | B | 7.94 | pKi | 11.5 | nM | Ki | Eur J Med Chem (2011) 46: 2992-2999 [PMID:21550699] |
| ChEMBL | Displacement of [3H]raclopride from rat dopamine D2short receptor expressed in CHO-K1 cells by liquid scintillation counting | B | 7.94 | pKi | 11.5 | nM | Ki | Bioorg Med Chem (2009) 17: 4756-4762 [PMID:19454369] |
| ChEMBL | Binding affinity at rat striatal Dopamine receptor D2 using [3H]- piperone radioligand | B | 7.95 | pKi | 11.1 | nM | Ki | J Med Chem (1990) 33: 1800-1805 [PMID:1971309] |
| ChEMBL | Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membrane | B | 7.95 | pKi | 11.1 | nM | Ki | Bioorg Med Chem (2008) 16: 4563-4568 [PMID:18313931] |
| ChEMBL | Tested for binding affinity towards rat striatal D2 receptor using [3H]NPA as radioligand | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (1994) 37: 3523-3533 [PMID:7932581] |
| ChEMBL | Displacement of [3H]neomonapride from dopamine D2 receptor in rat striatum | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (2008) 51: 983-987 [PMID:18251489] |
| ChEMBL | Displacement of [3H]domperidone from dopamine D2 receptor high binding site in Sprague-Dawley rat striatum by scintillation counting | B | 8.74 | pKi | 1.8 | nM | Ki | ACS Med Chem Lett (2011) 2: 189-194 [PMID:21666830] |
| ChEMBL | Neuroleptic activity in terms of [3H]spiroperidol binding in rat striatal membrane to Dopamine receptor D2 | B | 6.52 | pIC50 | 302 | nM | IC50 | J Med Chem (1991) 34: 194-197 [PMID:1671414] |
| ChEMBL | Inhibition of binding of [3H]spiroperidol to Dopamine receptor D2 in rat striatal membranes | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 883-886 [PMID:11294383] |
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 6.87 | pIC50 | 135 | nM | IC50 | Med Chem Res (2004) 13: 25-33 |
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 6.93 | pIC50 | 118 | nM | IC50 | Med Chem Res (2004) 13: 25-33 |
| ChEMBL | Compound was evaluated for the inhibition of [3H]spiperone binding to Dopamine receptor D2 of rat striatal membranes | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (1990) 33: 2408-2412 [PMID:1975274] |
| ChEMBL | Binding affinity against Dopamine receptor D2 from rat brain corpus striatum membrane | B | 7.18 | pIC50 | 66.7 | nM | IC50 | J Med Chem (1990) 33: 3122-3124 [PMID:2147956] |
| ChEMBL | Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1990) 33: 311-317 [PMID:1967314] |
| ChEMBL | Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain. | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1990) 33: 445-450 [PMID:1967318] |
| ChEMBL | In vitro binding affinity to Dopamine receptor D2 in rat striatal membranes using D2 antagonist [3H]spiperone | B | 7.62 | pIC50 | 24.1 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 539-544 |
| ChEMBL | Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]-spiperone as ligand; Value ranges from (20-29) | F | 7.62 | pIC50 | 24.1 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 189-192 |
| ChEMBL | Displacement of [3H]spiperone from rat striatal Dopamine receptor D2 | B | 7.62 | pIC50 | 24 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 639-644 |
| ChEMBL | Compound was tested in vitro for binding affinity towards Dopamine receptor D2 in rat striatal membrane by using [3H]spiperone as radioligand | B | 7.62 | pIC50 | 24 | nM | IC50 | J Med Chem (1991) 34: 2736-2746 [PMID:1680195] |
| ChEMBL | In vitro binding affinity towards rat Dopamine receptor D2 by [3H]spiperone displacement. | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1990) 33: 600-607 [PMID:2405158] |
| ChEMBL | Inhibitory concentration against radioligand [3H](-)-sulpiride binding to Dopamine receptor D2 in rat | B | 8.29 | pIC50 | 5.1 | nM | IC50 | J Med Chem (1999) 42: 1076-1087 [PMID:10090790] |
| ChEMBL | Inhibition of [3H]N-propylnorapomorphine as radioligand for Dopamine receptor D2 in rat striatal membranes | B | 8.59 | pIC50 | 2.6 | nM | IC50 | J Med Chem (1990) 33: 311-317 [PMID:1967314] |
| ChEMBL | Affinity for [3H]N-propylnorapomorphine (NPA) Dopamine receptor D2 | B | 8.59 | pIC50 | 2.6 | nM | IC50 | J Med Chem (1990) 33: 445-450 [PMID:1967318] |
| ChEMBL | In vitro agonist binding affinity was determined by displacing the [3H]N-propylnorapomorphine ([3H]NPA) in rat striatal Dopamine receptor D2 | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 639-644 |
| ChEMBL | Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine agonist [3H]N-propylnorapomorphine as ligand; Value ranges from (1.4-1.9) | F | 8.77 | pIC50 | 1.7 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 189-192 |
| ChEMBL | Evaluated for the affinity against Dopamine receptor D2 in rat striatal membranes | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1988) 31: 1466-1471 [PMID:2968456] |
| ChEMBL | Agonist activity at rat dopamine D2short receptor expressed in CHO-K1 cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting | F | 7.28 | pEC50 | 53 | nM | EC50 | Bioorg Med Chem (2009) 17: 4756-4762 [PMID:19454369] |
| ChEMBL | Agonist activity at rat D2 dopamine receptor expressed in CHOK1 cells assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counter | F | 7.52 | pEC50 | 30 | nM | EC50 | Eur J Med Chem (2011) 46: 2992-2999 [PMID:21550699] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay | B | 8.74 | pEC50 | 1.8 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay | B | 9.4 | pEC50 | 0.4 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 9.4 | pEC50 | 0.4 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| GtoPdb | - | - | 7.6 | pKi | - | - | - |
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]; J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Neuroreport (1995) 6: 329-332 [PMID:7756621]; Neuropsychopharmacology (1995) 12: 335-45 [PMID:7576010]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163] |
| ChEMBL | Displacement of [3H]raclopride from human dopamine D3 receptor expressed in HEK293 cells by scintillation counting analysis | B | 7.77 | pKi | 17 | nM | Ki | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
| ChEMBL | Displacement of [3H]raclopride from human D3 receptor expressed in HEK293 cells | B | 8 | pKi | 10 | nM | Ki | Eur J Med Chem (2012) 55: 255-261 [PMID:22846798] |
| ChEMBL | Tested for binding affinity towards human D3 receptor using [3H]spiperone as radioligand | B | 8.11 | pKi | 7.8 | nM | Ki | J Med Chem (1994) 37: 3523-3533 [PMID:7932581] |
| ChEMBL | Displacement of [3H]domperidone from human cloned dopamine D3 receptor expressed in mouse CCL1-3 cells by scintillation counting | B | 8.59 | pKi | 2.6 | nM | Ki | ACS Med Chem Lett (2011) 2: 189-194 [PMID:21666830] |
| ChEMBL | Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation | F | 8.15 | pEC50 | 7 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 6691-6696 [PMID:17976986] |
| D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 7.53 | pIC50 | 29.4 | nM | IC50 | Med Chem Res (2004) 13: 25-33 |
| ChEMBL | Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting | B | 7.57 | pIC50 | 27.2 | nM | IC50 | Med Chem Res (2004) 13: 25-33 |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membrane | B | 8.05 | pKi | 8.9 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| GtoPdb | - | - | 8.4 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D4 using FLIPR assay | B | 8.37 | pEC50 | 4.3 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 8.37 | pEC50 | 4.3 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay | B | 8.26 | pEC50 | 5.5 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 8.26 | pEC50 | 5.5 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay | B | 8.82 | pEC50 | 1.5 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
| GtoPdb | - | - | 7.8 | pKi | - | - | - |
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]; Nature (1991) 350: 614-9 [PMID:1826762] |
| ChEMBL | Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127053-127053 [PMID:32107165] |
| MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987] | ||||||||
| ChEMBL | Inhibition of biotin-labelled P4 peptide binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance method | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2571-2574 [PMID:28400230] |
| ChEMBL | Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization assay | B | 6.67 | pIC50 | 215 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2571-2574 [PMID:28400230] |
| ChEMBL | Inhibition of biotin-labelled D-p53 binding to D-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization assay | B | 6.71 | pIC50 | 195 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2571-2574 [PMID:28400230] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus. | B | 6.27 | pKi | 534 | nM | Ki | J Med Chem (1992) 35: 1076-1092 [PMID:1348089] |
| ChEMBL | Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT | B | 6.53 | pKi | 296 | nM | Ki | J Med Chem (2000) 43: 1339-1349 [PMID:10753471] |
| ChEMBL | In vitro binding affinity towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [3H]8-OH-DPAT as radioligand | B | 6.53 | pKi | 296 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 367-370 [PMID:11212112] |
| ChEMBL | Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | B | 6.53 | pKi | 296 | nM | Ki | J Med Chem (2001) 44: 1337-1340 [PMID:11311055] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| ChEMBL | Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in CHO cells incubated for 150 mins by radio ligand binding assay | B | 6.93 | pKi | 117 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127053-127053 [PMID:32107165] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Ability to displace [3H]8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor | B | 6.53 | pKi | 296 | nM | Ki | J Med Chem (1995) 38: 647-658 [PMID:7861413] |
| ChEMBL | In vitro displacement of [3H]8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor | B | 6.53 | pKi | 296 | nM | Ki | J Med Chem (1996) 39: 3503-3513 [PMID:8784448] |
| ChEMBL | In vitro affinity at 5-hydroxytryptamine 1A receptor of rat hippocampus by [3H]8-OH-DPAT displacement. | B | 6.53 | pKi | 296 | nM | Ki | J Med Chem (1996) 39: 3491-3502 [PMID:8784447] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| ChEMBL | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells incubated for 40 mins by radio ligand binding assay | B | 6.92 | pKi | 120 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127053-127053 [PMID:32107165] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
| ChEMBL | Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT | B | 6.73 | pKi | 188 | nM | Ki | J Med Chem (2000) 43: 1339-1349 [PMID:10753471] |
| ChEMBL | In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand | B | 6.73 | pKi | 188 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 367-370 [PMID:11212112] |
| ChEMBL | Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells | B | 6.73 | pKi | 188 | nM | Ki | J Med Chem (2001) 44: 1337-1340 [PMID:11311055] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranes | B | 4.51 | pIC50 | >31000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| ChEMBL | Inhibition of specific binding of [125I]-PIPAG to sigma binding site in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| ChEMBL | Inhibition of specific binding of [3H]DTG to sigma binding site in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
| ChEMBL | Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 1076-1087 [PMID:10090790] |
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.68 | pIC50 | 20800 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| GtoPdb | - | - | 7.2 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| GtoPdb | - | - | 7.4 | pKi | - | - | - | J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666] |
| TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| GtoPdb | Calcium imaging, patch clamp | - | 5.1 | pEC50 | - | - | - | Mol Pharmacol (2013) 83: 542-51 [PMID:23220749] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
