[3H]PD128907 [Ligand Id: 3298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL97424 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay | B | 4 | pKi | >100000 | nM | Ki | ACS Med Chem Lett (2020) 11: 1956-1964 [PMID:33062179] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D2L expressed in CHO K-1 cells | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 2871-2882 [PMID:10956195] |
| ChEMBL | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | B | 5.12 | pKi | 7580 | nM | Ki | ACS Med Chem Lett (2020) 11: 1956-1964 [PMID:33062179] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain. | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1990) 33: 445-450 [PMID:1967318] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| GtoPdb | - | - | 9 | pKd | 0.99 | nM | Kd | Life Sci (1995) 57: 1401-10 [PMID:7674830] |
| ChEMBL | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cells | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 2871-2882 [PMID:10956195] |
| ChEMBL | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | B | 5.25 | pKi | 5620 | nM | Ki | ACS Med Chem Lett (2020) 11: 1956-1964 [PMID:33062179] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [3H]-DAMGO from human MOR expressed in HEK293 cells after 60 mins by microbeta counting based assay | B | 4.11 | pKi | 77900 | nM | Ki | ACS Med Chem Lett (2020) 11: 1956-1964 [PMID:33062179] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
