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ChEMBL ligand: CHEMBL477 (9-.beta.-d-ribofuranosyladenine, Adenocard, Adenocor, Adenoscan, Adenosine, NSC-7652, SR 96225, SR-96225) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Inhibition of CA200645 binding to NanoLuc-fused human adenosine A1 receptor expressed in HEK293 cells assessed as kinetic dissociation constant by NanoBRET competition binding assay | B | 6.53 | pKd | 295.12 | nM | Kd | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
ChEMBL | Inhibition of CA200645 binding to NanoLuc-fused human adenosine A1 receptor expressed in HEK293 cells measured for 10 mins by NanoBRET competition binding assay | B | 6.09 | pKi | 812.83 | nM | Ki | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
GtoPdb | - | - | 7 | pKi | ~100 | nM | Ki | Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis | F | 8.63 | pIC50 | 2.34 | nM | IC50 | J Med Chem (2016) 59: 947-964 [PMID:26756468] |
ChEMBL | Agonist activity at human Adenosine A1 receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphai1 after 16 hrs by beta galactosidase reporter gene assay | B | 5.6 | pEC50 | 2511.89 | nM | EC50 | J Med Chem (2016) 59: 947-964 [PMID:26756468] |
ChEMBL | Agonist activity at human A1AR assessed as induction of Ca2+ ion mobilization by orthogonal functional assay | F | 5.85 | pEC50 | 1410 | nM | EC50 | J Med Chem (2012) 55: 6467-6477 [PMID:22738238] |
ChEMBL | Agonist activity at human recombinant adenosine A1 receptor by cAMP assay | F | 6.51 | pEC50 | 310 | nM | EC50 | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as increase of intracellular calcium level | F | 6.51 | pEC50 | 310 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4140-4146 [PMID:20541935] |
ChEMBL | Agonist activity at human adenosine A1 receptor expressed in CHO cells | F | 6.51 | pEC50 | 310 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1933-1936 [PMID:21388809] |
ChEMBL | Agonist activity at human adenosine A1 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine | F | 6.51 | pEC50 | 310 | nM | EC50 | J Med Chem (2016) 59: 788-809 [PMID:26356532] |
ChEMBL | Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay | F | 7.16 | pEC50 | 69.18 | nM | EC50 | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
ChEMBL | Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay | F | 7.41 | pEC50 | 39 | nM | EC50 | J Med Chem (2012) 55: 6467-6477 [PMID:22738238] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Inhibition of CA200645 binding to NanoLuc-fused rat adenosine A1 receptor expressed in HEK293 cells assessed as kinetic dissociation constant by NanoBRET competition binding assay | B | 5.71 | pKd | 1949.84 | nM | Kd | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
ChEMBL | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | B | 4.54 | pKi | 29000 | nM | Ki | J Med Chem (1995) 38: 1174-1188 [PMID:7707320] |
ChEMBL | Inhibition of CA200645 binding to NanoLuc-fused rat adenosine A1 receptor expressed in HEK293 cells measured for 10 mins by NanoBRET competition binding assay | B | 6.06 | pKi | 870.96 | nM | Ki | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
GtoPdb | - | - | 7.14 | pKi | 73 | nM | Ki | Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Affinity for Adenosine A1 receptor determined by [3H]N6-cyclohexyladenosine binding to rat brain membranes | B | 7.89 | pKi | 12.8 | nM | Ki | Bioorg Med Chem Lett (1991) 1: 481-486 |
ChEMBL | Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. | B | 7.89 | pKi | 12.8 | nM | Ki | J Med Chem (1989) 32: 1667-1673 [PMID:2754691] |
ChEMBL | Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2000) 43: 2196-2203 [PMID:10841798] |
ChEMBL | Evaluated for the binding affinity towards the Adenosine A1 receptor in corpora striata of rats using [3H]CHA as radioligand. | B | 8 | pKi | 10 | nM | Ki | J Med Chem (1990) 33: 2240-2254 [PMID:2374150] |
ChEMBL | Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor | B | 8.29 | pKi | 5.1 | nM | Ki | J Med Chem (1990) 33: 3127-3130 [PMID:2258897] |
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] | ||||||||
ChEMBL | Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the A1 adenosine receptor in langendorff guinea pig heart preparation | F | 5.47 | pEC50 | 3388.44 | nM | EC50 | J Med Chem (1991) 34: 1340-1344 [PMID:2016708] |
ChEMBL | Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparation | F | 5.47 | pEC50 | 3388.44 | nM | EC50 | J Med Chem (1991) 34: 1334-1339 [PMID:2016707] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay | B | 7.76 | pKd | 17.3 | nM | Kd | ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869] |
ChEMBL | Binding affinity to human recombinant adenosine receptor A2A expressed in CHO cells assessed as inhibitory constant by radioligand competition assay | B | 6.15 | pKi | 700 | nM | Ki | Eur J Med Chem (2019) 179: 310-324 [PMID:31255928] |
GtoPdb | - | - | 6.51 | pKi | 310 | nM | Ki |
Annu Rev Pharmacol Toxicol (2005) 45: 385-412 [PMID:15822182]; Pharmacol Toxicol (1995) 76: 93-101 [PMID:7746802]; Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay | B | 6.82 | pKi | 150 | nM | Ki | ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869] |
ChEMBL | Binding affinity to A2A adenosine receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2012) 55: 538-552 [PMID:22104008] |
ChEMBL | Effective concentration required for cyclic AMP dependent inhibition of blood platelet aggregation for A2 receptor stimulation | B | 4.4 | pEC50 | 40000 | nM | EC50 | J Med Chem (1993) 36: 4113-4120 [PMID:8258836] |
ChEMBL | Agonist activity at human Adenosine A2A receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay | B | 5.24 | pEC50 | 5754.4 | nM | EC50 | J Med Chem (2016) 59: 947-964 [PMID:26756468] |
ChEMBL | Agonist activity at human adenosine A2A receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine | F | 6.14 | pEC50 | 730 | nM | EC50 | J Med Chem (2016) 59: 788-809 [PMID:26356532] |
ChEMBL | Agonist activity at human recombinant adenosine receptor A2a by cAMP assay | F | 6.15 | pEC50 | 700 | nM | EC50 | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as increase of intracellular calcium level | F | 6.15 | pEC50 | 700 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4140-4146 [PMID:20541935] |
ChEMBL | Agonist activity at human adenosine A2A receptor expressed in CHO cells | F | 6.15 | pEC50 | 700 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1933-1936 [PMID:21388809] |
ChEMBL | Agonist activity at human adenosine A2A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay | F | 7.6 | pEC50 | 25.12 | nM | EC50 | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranes | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2000) 43: 2196-2203 [PMID:10841798] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 4.82 | pKi | 15000 | nM | Ki |
Annu Rev Pharmacol Toxicol (2005) 45: 385-412 [PMID:15822182]; Pharmacol Toxicol (1995) 76: 93-101 [PMID:7746802]; Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay | B | 4.29 | pEC50 | 51286.14 | nM | EC50 | J Med Chem (2016) 59: 947-964 [PMID:26756468] |
ChEMBL | Agonist activity at human adenosine A2B receptor expressed in CHO cells | F | 4.62 | pEC50 | 24000 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1933-1936 [PMID:21388809] |
ChEMBL | Agonist activity at human recombinant adenosine receptor A2b by cAMP assay | F | 4.62 | pEC50 | 24000 | nM | EC50 | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level | F | 4.62 | pEC50 | 24000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4140-4146 [PMID:20541935] |
ChEMBL | Agonist activity at A2B receptor (unknown origin) | B | 4.62 | pEC50 | 24000 | nM | EC50 | J Med Chem (2021) 64: 458-480 [PMID:33372800] |
ChEMBL | Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine | F | 4.63 | pEC50 | 23500 | nM | EC50 | J Med Chem (2016) 59: 788-809 [PMID:26356532] |
ChEMBL | Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay | F | 7.28 | pEC50 | 52.48 | nM | EC50 | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
A2B receptor in Rat [GtoPdb: 20] [UniProtKB: P29276] | ||||||||
GtoPdb | - | - | 5.29 | pKi | 5100 | nM | Ki | Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay | B | 6.13 | pKd | 740 | nM | Kd | ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869] |
ChEMBL | Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay | B | 6.54 | pKi | 290 | nM | Ki | ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869] |
GtoPdb | - | - | 6.54 | pKi | 290 | nM | Ki |
Annu Rev Pharmacol Toxicol (2005) 45: 385-412 [PMID:15822182]; Pharmacol Toxicol (1995) 76: 93-101 [PMID:7746802]; Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis | F | 8.94 | pIC50 | 1.15 | nM | IC50 | J Med Chem (2016) 59: 947-964 [PMID:26756468] |
ChEMBL | Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay | F | 5.98 | pEC50 | 1040 | nM | EC50 | J Med Chem (2006) 49: 2689-2702 [PMID:16640329] |
ChEMBL | Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level | F | 6.54 | pEC50 | 290 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4140-4146 [PMID:20541935] |
ChEMBL | Agonist activity at human adenosine A3 receptor expressed in CHO cells | F | 6.54 | pEC50 | 290 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1933-1936 [PMID:21388809] |
ChEMBL | Agonist activity at human recombinant adenosine A3 receptor by cAMP assay | F | 6.54 | pEC50 | 290 | nM | EC50 | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine | F | 6.54 | pEC50 | 290 | nM | EC50 | J Med Chem (2016) 59: 788-809 [PMID:26356532] |
ChEMBL | Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay | F | 7.87 | pEC50 | 13.49 | nM | EC50 | J Med Chem (2022) 65: 14864-14890 [PMID:36270633] |
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
GtoPdb | - | - | 5.19 | pKi | 6500 | nM | Ki | Expert Opin Emerg Drugs (2003) 8: 537-76 [PMID:14662005] |
ChEMBL | Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in CHO cells | B | 7 | pKi | 100 | nM | Ki | J Med Chem (2000) 43: 2196-2203 [PMID:10841798] |
Adenosine kinase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2982] [UniProtKB: Q9TVW2] | ||||||||
ChEMBL | Binding affinity to purified Toxoplasma gondii adenosine kinase | B | 5.05 | pKi | 8900 | nM | Ki | J Med Chem (2008) 51: 3934-3945 [PMID:18563892] |
cAMP-dependent protein kinase A in Bovine (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111446] [UniProtKB: P00515, P00517, P05131, P31322] | ||||||||
ChEMBL | Inhibitory constant for Protein Kinase A | B | 4.82 | pKi | 15000 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 899-902 |
heat shock protein 90 beta family member 1/Endoplasmin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075323] [GtoPdb: 2904] [UniProtKB: P14625] | ||||||||
ChEMBL | Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay | B | 4.3 | pKd | >50000 | nM | Kd | ACS Med Chem Lett (2021) 12: 373-379 [PMID:33738064] |
ChEMBL | Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay | B | 5 | pKi | >10000 | nM | Ki | ACS Med Chem Lett (2021) 12: 373-379 [PMID:33738064] |
Equilibrative nucleoside transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1997] [GtoPdb: 1117] [UniProtKB: Q99808] | ||||||||
ChEMBL | Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861) | F | 4.2 | pEC50 | 63000 | nM | EC50 | Sci Rep (2019) 9: 13802-null [PMID:31551431] |
Glyceraldehyde-3-phosphate dehydrogenase liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2284] [UniProtKB: P04406] | ||||||||
ChEMBL | Inhibition of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei | B | 1 | pIC50 | 100000000 | nM | IC50 | J Med Chem (1995) 38: 3838-3849 [PMID:7562915] |
ChEMBL | Inhibitory activity measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana | B | 1.3 | pIC50 | 50000000 | nM | IC50 | J Med Chem (1998) 41: 4790-4799 [PMID:9822549] |
ChEMBL | TInhibition of glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana | B | 1.3 | pIC50 | 50000000 | nM | IC50 | J Med Chem (1995) 38: 3838-3849 [PMID:7562915] |
ChEMBL | Inhibition of Glyceraldehyde-3-phosphate dehydrogenase in human erythrocytes. | B | 1.46 | pIC50 | 35000000 | nM | IC50 | J Med Chem (1995) 38: 3838-3849 [PMID:7562915] |
ChEMBL | Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of Trypanosoma brucei | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (1994) 37: 3605-3613 [PMID:7932587] |
ChEMBL | Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of Leishmania mexicana | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (1994) 37: 3605-3613 [PMID:7932587] |
ChEMBL | Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of human erythrocyte | B | 4.46 | pIC50 | 35000 | nM | IC50 | J Med Chem (1994) 37: 3605-3613 [PMID:7932587] |
DOT1 like histone lysine methyltransferase/Histone-lysine N-methyltransferase, H3 lysine-79 specific in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795117] [GtoPdb: 2650] [UniProtKB: Q8TEK3] | ||||||||
ChEMBL | Inhibition of DOT1L (2 to 416 residues) (unknown origin) using biotinylated nucleosomes as substrate preincubated for 30 mins followed by substrate addition in presence of [3H-Me]SAM by scintillation proximity assay | B | 4 | pIC50 | 100000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 338-343 [PMID:28337327] |
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839] | ||||||||
ChEMBL | Inhibition of human IMP dehydrogenase 1 | B | 4 | pKi | >100000 | nM | Ki | Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139] |
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] | ||||||||
ChEMBL | Inhibition of human IMP dehydrogenase 2 | B | 4 | pKi | >100000 | nM | Ki | Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139] |
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
ChEMBL | Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 residues) expressed in baculovirus infected sf9 cells by SPR assay | B | 4.47 | pKd | 34000 | nM | Kd | Bioorg Med Chem Lett (2017) 27: 1031-1036 [PMID:28109791] |
ChEMBL | Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 residues) expressed in baculovirus infected sf9 cells by SPR assay | B | 5.36 | pKd | 4400 | nM | Kd | Bioorg Med Chem Lett (2017) 27: 1031-1036 [PMID:28109791] |
TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
GtoPdb | - | - | 3.2 | pIC50 | 630000 | nM | IC50 | |
phosphatidylinositol 4-kinase type 2 alpha in Human [GtoPdb: 2498] [UniProtKB: Q9BTU6] | ||||||||
GtoPdb | - | - | 5 | pIC50 | - | - | - | Anal Biochem (2011) 417: 97-102 [PMID:21704602] |
phosphatidylinositol 4-kinase type 2 beta in Human [GtoPdb: 2499] [UniProtKB: Q8TCG2] | ||||||||
GtoPdb | - | - | 5 | pIC50 | - | - | - | Anal Biochem (2011) 417: 97-102 [PMID:21704602] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]