diclofenac [Ligand Id: 2714] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL139 (Arthrotec, Cambia, Cataflam, Diclofenac, Diclofenac acid, Diclofenac free acid, Las41007, LAS-41007, LAS41007, Solaraze, Voltaren, Voltaren Ophthalmic, Voltaren Xr, Voltaren-XR, Zorvolex, Zorvolex capsules) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
| ChEMBL | Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction by spectrophotometry | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2015) 58: 2047-2067 [PMID:25375908] |
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of human AR by fluorescence assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2015) 58: 2047-2067 [PMID:25375908] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase I was determined | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase II was determined | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV was determined | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX was determined | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay | B | 4.74 | pIC50 | 18230 | nM | IC50 | ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915] |
| ChEMBL | In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1 | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640] |
| ChEMBL | Inhibition of COX1 | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2007) 50: 1425-1441 [PMID:17341061] |
| ChEMBL | Inhibition of human COX1 expressed in sf9 cells | B | 7.52 | pIC50 | 30 | nM | IC50 | J Nat Prod (2005) 68: 1514-1518 [PMID:16252917] |
| ChEMBL | Inhibition of human cyclooxygenase 1 | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 7.89 | pIC50 | 13 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | J Nat Prod (2005) 68: 1514-8 [PMID:16252917] |
| ChEMBL | Inhibition of COX1 assessed as inhibition of arachidonic acid conversion to prostaglandin-E2 release | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2009) 52: 1115-1125 [PMID:19191553] |
| ChEMBL | Inhibition of cyclooxygenase 1 | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2008) 51: 6348-6358 [PMID:18811132] |
| ChEMBL | Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2 | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2008) 51: 260-270 [PMID:18095641] |
| ChEMBL | Inhibition of COX1 | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2012) 55: 2932-2942 [PMID:22236250] |
| Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664] | ||||||||
| ChEMBL | Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay | B | 4.73 | pIC50 | 18790 | nM | IC50 | Eur J Med Chem (2019) 180: 86-98 [PMID:31301566] |
| ChEMBL | Inhibition of ovine COX1 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay | B | 5.2 | pIC50 | 6250 | nM | IC50 | Bioorg Med Chem (2014) 22: 2855-2866 [PMID:24751552] |
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 5.2 | pIC50 | 6240 | nM | IC50 | Eur J Med Chem (2017) 127: 10-21 [PMID:28038322] |
| ChEMBL | Inhibition of ovine COX -1 by colorimetric inhibitor screening assay kit method | B | 5.41 | pIC50 | 3900 | nM | IC50 | Eur J Med Chem (2019) 167: 161-186 [PMID:30771604] |
| ChEMBL | Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis | B | 6.21 | pIC50 | 610 | nM | IC50 | Eur J Med Chem (2015) 97: 104-123 [PMID:25956953] |
| ChEMBL | Inhibition of sheep COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by UV-visible spectrophotometric method | B | 6.32 | pIC50 | 480 | nM | IC50 | Eur J Med Chem (2020) 186: 111863-111863 [PMID:31740050] |
| ChEMBL | Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay | B | 6.49 | pIC50 | 320 | nM | IC50 | ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653] |
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 6.6 | pIC50 | 250 | nM | IC50 | Medchemcomm (2016) 7: 2309-2327 |
| ChEMBL | Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2015) 92: 115-123 [PMID:25549551] |
| ChEMBL | Inhibition of ovine COX1 after 2 mins by EIA | B | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2014) 80: 167-174 [PMID:24780593] |
| ChEMBL | Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741] |
| ChEMBL | Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2021) 64: 9550-9566 [PMID:34137625] |
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 77-82 [PMID:24332492] |
| ChEMBL | Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2016) 59: 3920-3934 [PMID:27019010] |
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins followed by substrate addition and measured after 2 mins by EIA assay | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem (2020) 28: 115246-115246 [PMID:31843462] |
| ChEMBL | Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid | B | 7.17 | pIC50 | 67 | nM | IC50 | J Biol Chem (2007) 282: 16379-16390 [PMID:17434872] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell | B | 4.63 | pIC50 | 23620 | nM | IC50 | Eur J Med Chem (2010) 45: 6135-6138 [PMID:20974503] |
| ChEMBL | Inhibition of human COX2 expressed in baculovirus infected sf21 cells assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay | B | 4.63 | pIC50 | 23620 | nM | IC50 | ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915] |
| ChEMBL | Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay | B | 4.77 | pIC50 | 16900 | nM | IC50 | ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653] |
| ChEMBL | Inhibition of human COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 5.53 | pIC50 | 2940 | nM | IC50 | Eur J Med Chem (2017) 127: 10-21 [PMID:28038322] |
| ChEMBL | Inhibition of human recombinant COX2 after 2 mins by EIA | B | 5.57 | pIC50 | 2700 | nM | IC50 | Eur J Med Chem (2014) 80: 167-174 [PMID:24780593] |
| ChEMBL | Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay | B | 5.91 | pIC50 | 1240 | nM | IC50 | Eur J Med Chem (2019) 180: 86-98 [PMID:31301566] |
| ChEMBL | Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis | B | 6.2 | pIC50 | 630 | nM | IC50 | Eur J Med Chem (2015) 97: 104-123 [PMID:25956953] |
| ChEMBL | Inhibition of human COX2 expressed in sf9 cells | B | 7.15 | pIC50 | 70 | nM | IC50 | J Nat Prod (2005) 68: 1514-1518 [PMID:16252917] |
| ChEMBL | Inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741] |
| ChEMBL | In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2 | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640] |
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) | B | 7.43 | pIC50 | 37 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid | B | 7.55 | pIC50 | 28 | nM | IC50 | J Biol Chem (2007) 282: 16379-16390 [PMID:17434872] |
| ChEMBL | Inhibitory concentration against COX-2; (valus obtained by Kato et al.) | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2005) 48: 6997-7004 [PMID:16250658] |
| ChEMBL | Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2021) 64: 9550-9566 [PMID:34137625] |
| ChEMBL | Inhibition of COX2 | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2007) 50: 1425-1441 [PMID:17341061] |
| ChEMBL | Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 77-82 [PMID:24332492] |
| ChEMBL | Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2016) 59: 3920-3934 [PMID:27019010] |
| ChEMBL | Inhibition of human COX2 using arachidonic acid as substrate incubated for 10 mins followed by substrate addition and measured after 2 mins by EIA assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem (2020) 28: 115246-115246 [PMID:31843462] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2007) 50: 1425-41 [PMID:17341061] |
| ChEMBL | Inhibition of COX2 in LPS-stimulated human blood | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
| ChEMBL | Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2005) 48: 6997-7004 [PMID:16250658] |
| ChEMBL | Inhibition of COX2 | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2012) 55: 2932-2942 [PMID:22236250] |
| Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208] | ||||||||
| ChEMBL | Inhibition of ovine COX2 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay | B | 4.82 | pIC50 | 15000 | nM | IC50 | Bioorg Med Chem (2014) 22: 2855-2866 [PMID:24751552] |
| ChEMBL | Inhibition of ovine COX2 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay | B | 5.38 | pIC50 | 4200 | nM | IC50 | Eur J Med Chem (2015) 92: 115-123 [PMID:25549551] |
| ChEMBL | Inhibition of ovine COX -2 by colorimetric inhibitor screening assay kit method | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2019) 167: 161-186 [PMID:30771604] |
| ChEMBL | Inhibition of ovine COX2 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay | B | 6.59 | pIC50 | 260 | nM | IC50 | Medchemcomm (2016) 7: 2309-2327 |
| ChEMBL | Inhibition of sheep placental cotyledons COX2 | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2011) 54: 8555-8562 [PMID:22091869] |
| COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] | ||||||||
| ChEMBL | Inhibition of purified mouse COX-2 assessed as inhibition of PGE2/PGD2 formation preincubated for 15 mins before arachidonic acid substrate addition measured after 30 seconds by LC-MS-MS method | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5860-5864 [PMID:24060487] |
| ChEMBL | Inhibition of mouse wild type COX2 | B | 7.11 | pIC50 | 77 | nM | IC50 | J Med Chem (2007) 50: 1425-1441 [PMID:17341061] |
| ChEMBL | Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 15 mins before 2-AG substrate addition measured after 30 seconds by LC-MS-MS method | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5860-5864 [PMID:24060487] |
| ChEMBL | Inhibition of mouse COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid | B | 7.66 | pIC50 | 22 | nM | IC50 | J Biol Chem (2007) 282: 16379-16390 [PMID:17434872] |
| ChEMBL | Inhibition of mouse COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acid | B | 7.66 | pIC50 | 22 | nM | IC50 | J Biol Chem (2007) 282: 16379-16390 [PMID:17434872] |
| Cytochrome c oxidase subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6174] [UniProtKB: P00403] | ||||||||
| ChEMBL | Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by UV-visible spectrophotometric method | B | 5 | pIC50 | 10050 | nM | IC50 | Eur J Med Chem (2020) 186: 111863-111863 [PMID:31740050] |
| fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] | ||||||||
| ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 4.45 | pKi | 35400 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 5.49 | pKi | 3220 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| Interleukin-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157] [UniProtKB: P10145] | ||||||||
| ChEMBL | Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4026-4030 [PMID:19560921] |
| CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] | ||||||||
| ChEMBL | Inhibition of CXCR1 Lys99Ala mutant transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured after 4 hrs | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4026-4030 [PMID:19560921] |
| ChEMBL | Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured after 4 hrs | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4026-4030 [PMID:19560921] |
| Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells | F | 5.4 | pIC50 | 4000 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 10-15 [PMID:10991954] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.2 | pEC50 | 63095.73 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.25 | pEC50 | 56000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2015) 58: 6507-6515 [PMID:26214366] |
| ChEMBL | Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopy | B | 7.22 | pKd | 60 | nM | Kd | J Med Chem (2020) 63: 14228-14242 [PMID:32914975] |
| UDP glucuronosyltransferase family 1 member A1/UDP-glucuronosyltransferase 1-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287617] [GtoPdb: 2990] [UniProtKB: P22309] | ||||||||
| ChEMBL | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1 | B | 4.28 | pKi | 52000 | nM | Ki | Pharmacol Ther (2005) 106: 97-132 [PMID:15781124] |
| UDP-glucuronosyltransferase 1-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743320] [UniProtKB: Q9HAW8] | ||||||||
| ChEMBL | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10 | B | 4.55 | pKi | 28000 | nM | Ki | Pharmacol Ther (2005) 106: 97-132 [PMID:15781124] |
| UDP-glucuronosyltransferase 1-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743316] [UniProtKB: P19224] | ||||||||
| ChEMBL | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A6 | B | 4.64 | pKi | 23000 | nM | Ki | Pharmacol Ther (2005) 106: 97-132 [PMID:15781124] |
| UDP-glucuronosyltransferase 1-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7] | ||||||||
| ChEMBL | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A7 | B | 4.72 | pKi | 19000 | nM | Ki | Pharmacol Ther (2005) 106: 97-132 [PMID:15781124] |
| UDP-glucuronosyltransferase 1-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743319] [UniProtKB: O60656] | ||||||||
| ChEMBL | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9 | B | 4.96 | pKi | 11000 | nM | Ki | Pharmacol Ther (2005) 106: 97-132 [PMID:15781124] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 4.89 | pIC50 | 12890 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
| GtoPdb | - | - | 5.2 | pIC50 | - | - | - | Pharmacol Res Perspect (2016) 4: e00232 [PMID:27433342] |
| Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| GtoPdb | - | - | 6.2 | pKi | - | - | - | Mol Pharmacol (2002) 61: 7-12 [PMID:11752200] |
| ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | 92000 | nM | IC50 | J Neurosci (2001) 21: 8026-33 [PMID:11588175] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
