ChEMBL ligand: CHEMBL187266 (Tanshinone IIA)
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 2/Carboxylesterase 2 in Human [ChEMBL: CHEMBL3180] [GtoPdb: 3298] [UniProtKB: O00748] There should be some charts here, you may need to enable JavaScript!
DNA-(apurinic or apyrimidinic site) lyase in Human [ChEMBL: CHEMBL5619] [UniProtKB: P27695] There should be some charts here, you may need to enable JavaScript!
embryonic ectoderm development/enhancer of zeste 2 polycomb repressive complex 2 subunit/EZH2/SUZ12/EED complex in Human [ChEMBL: CHEMBL3137286] [GtoPdb: 2487, 2654] [UniProtKB: O75530, Q15022, Q15910] There should be some charts here, you may need to enable JavaScript!
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
Protein-tyrosine phosphatase 1C in Human [ChEMBL: CHEMBL3166] [UniProtKB: P29350] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8] There should be some charts here, you may need to enable JavaScript!
Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746] There should be some charts here, you may need to enable JavaScript!
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of human BChE using butyrylthiocholine as substrate by spectrophotometric assay	B	4	pKi	>100000	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
ChEMBL	Inhibition of human AChE using acetylthiocholine as substrate by spectrophotometric assay	B	4	pKi	>100000	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
ChEMBL	Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay	B	5.16	pKi	6890	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry	B	5.06	pIC50	8690	nM	IC50	Bioorg Med Chem (2012) 20: 1251-1258 [PMID:22261024]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of Rattus norvegicus (rat) lens aldose reductase	B	5.94	pIC50	1148.15	nM	IC50	Med Chem Res (2012) 21: 1665-1676
ChEMBL	Inhibition of rat aldose reductase	B	5.94	pIC50	1140	nM	IC50	Bioorg Med Chem (2012) 20: 1251-1258 [PMID:22261024]
ChEMBL	Inhibition of rat lens aldose reductase	B	5.94	pIC50	1140	nM	IC50	Bioorg Med Chem (2012) 20: 1251-1258 [PMID:22261024]
carboxylesterase 2/Carboxylesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3180] [GtoPdb: 3298] [UniProtKB: O00748]
ChEMBL	Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay	B	5.61	pKi	2450	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
ChEMBL	Inhibition of human iCE using CPT-11 as substrate by spectrophotometric assay	B	7.16	pKi	69.4	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
GtoPdb	Inhibition of human CES2 using CPT-11 as substrate	-	7.16	pKi	69.4	nM	Ki	J Nat Prod (2013) 76: 36-44 [PMID:23286284]
DNA-(apurinic or apyrimidinic site) lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5619] [UniProtKB: P27695]
ChEMBL	Binding affinity to full length human APE1 expressed in Escherichia coli BL21/DE3	B	9.06	pKd	0.88	nM	Kd	Bioorg Med Chem (2017) 25: 2531-2544 [PMID:28161249]
embryonic ectoderm development/enhancer of zeste 2 polycomb repressive complex 2 subunit/EZH2/SUZ12/EED complex in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137286] [GtoPdb: 2487, 2654] [UniProtKB: O75530, Q15022, Q15910]
ChEMBL	Inhibition of EZH2 histone methyltransferase activity in EZH2/SUZ12/EED protein complex (unknown origin) using histone H3 peptide/S-adenosylmethionine as substrate after 2 hrs by TR-FRET assay	B	4.55	pIC50	28100	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2486-2492 [PMID:24767850]
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Inhibition of recombinant human IDO1 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate and measured after 15 mins	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2022) 235: 114294-114294 [PMID:35358772]
monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
ChEMBL	Inhibition of MAGL (unknown origin) after 10 mins	B	4.32	pIC50	48000	nM	IC50	Medchemcomm (2014) 5: 1528-1532
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity to PPARgamma (unknown origin)	B	5.59	pKi	2560	nM	Ki	Eur J Med Chem (2021) 221: 113535-113535 [PMID:33992930]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of Human immunodeficiency virus 1 protease preincubated for 10 mins by FRET assay	B	4.23	pIC50	59200	nM	IC50	Bioorg Med Chem (2012) 20: 5928-5935 [PMID:22884354]
Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
ChEMBL	Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincubated for 30 mins before substrate addition measured after 30 mins by phosphatase activity assay	B	5.67	pIC50	2140	nM	IC50	J Med Chem (2013) 56: 7212-7221 [PMID:23957426]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL	Inhibition of GST-tagged SHP2 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincubated for 30 mins before substrate addition measured after 30 mins by phosphatase activity assay	B	5.59	pIC50	2590	nM	IC50	J Med Chem (2013) 56: 7212-7221 [PMID:23957426]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of N-terminal 3xFlag-His6-tagged SARS-CoV-2 papain-like protease nsp3 (1564 to 1878 residues) expressed in baculovirus infected Sf9 insect cells using Pro3 as substrate by fluorescence based assay	B	5.8	pIC50	1571	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8]
ChEMBL	Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to 120 mins	B	4.95	pKi	11200	nM	Ki	Bioorg Med Chem (2012) 20: 5928-5935 [PMID:22884354]
ChEMBL	Inhibition of SARS-CoV 3CLpro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edan as substrate after 60 mins by FRET analysis	B	4.05	pIC50	89100	nM	IC50	Bioorg Med Chem (2012) 20: 5928-5935 [PMID:22884354]
ChEMBL	Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence assay	B	4.77	pIC50	17100	nM	IC50	Bioorg Med Chem (2012) 20: 5928-5935 [PMID:22884354]
ChEMBL	Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluorescence assay	B	5.8	pIC50	1600	nM	IC50	Bioorg Med Chem (2012) 20: 5928-5935 [PMID:22884354]
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL	Inhibition of human recombinant telomerase activity in rabbit reticulocytes after 90 mins by telomerase assemblage gel electrophoresis	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 7474-7478 [PMID:22044621]
ChEMBL	Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct primer extension assay	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2011) 21: 7474-7478 [PMID:22044621]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
ChEMBL	Inhibition of recombinant human TDO assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate and measured after 15 mins	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2022) 235: 114294-114294 [PMID:35358772]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]