luzindole [Ligand Id: 1363] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL286615 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
| ChEMBL | Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells | B | 6.1 | pKi | 794.33 | nM | Ki | Eur J Med Chem (2007) 42: 1004-1013 [PMID:17346859] |
| ChEMBL | Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay | B | 6.22 | pKi | 603 | nM | Ki | J Med Chem (2000) 43: 1050-1061 [PMID:10737738] |
| GtoPdb | - | - | 6.8 | pKi | - | - | - |
Br J Pharmacol (2000) 129: 877-86 [PMID:10696085]; Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]; Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 365-75 [PMID:9089668]; J Pharmacol Exp Ther (1988) 246: 902-10 [PMID:2843633] |
| ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells | B | 6.8 | pKi | 158 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
| ChEMBL | Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells | B | 7.33 | pKi | 46.77 | nM | Ki | Eur J Med Chem (2007) 42: 1004-1013 [PMID:17346859] |
| ChEMBL | Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay | B | 7.35 | pKi | 44.7 | nM | Ki | J Med Chem (2000) 43: 1050-1061 [PMID:10737738] |
| ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells | B | 7.99 | pKi | 10.2 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| GtoPdb | - | - | 8.1 | pKi | - | - | - |
Br J Pharmacol (2000) 129: 877-86 [PMID:10696085]; Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]; Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 365-75 [PMID:9089668]; FASEB J (1998) 12: 1211-20 [PMID:9737724]; J Pharmacol Exp Ther (1988) 246: 902-10 [PMID:2843633] |
| Melatonin receptor 1C in Xenopus laevis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5495] [UniProtKB: P49219] | ||||||||
| ChEMBL | Antagonist activity in Xenopus laevis melanophores assessed as melatoninergic activity after 60 mins | F | 5.61 | pIC50 | 2454.71 | nM | IC50 | Eur J Med Chem (2007) 42: 1004-1013 [PMID:17346859] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
