ChEMBL ligand: CHEMBL4789639 (Bms-986202, BMS986202)
Janus kinase 1/Janus kinase 3/JAK3/JAK1 in Human [ChEMBL: CHEMBL3038491] [GtoPdb: 2047, 2049] [UniProtKB: P23458, P52333] There should be some charts here, you may need to enable JavaScript!
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Mouse [ChEMBL: CHEMBL2321619] [GtoPdb: 2269] [UniProtKB: Q9R117] There should be some charts here, you may need to enable JavaScript!
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Janus kinase 1/Janus kinase 3/JAK3/JAK1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038491] [GtoPdb: 2047, 2049] [UniProtKB: P23458, P52333]
ChEMBL	Inhibition of JAK1/3 (unknown origin) by IL-2 dependent cell based assay	B	4.9	pIC50	>12500	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb	Binding affinity for Tyk2 JH2 domain	-	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	-	-	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321619] [GtoPdb: 2269] [UniProtKB: Q9R117]
ChEMBL	Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation	B	6.32	pIC50	481	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL	Inhibition of JAK1 JH2 domain (unknown origin)	B	8.11	pIC50	7.8	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Inhibition of JAK2 (unknown origin) by EPO-stimulated cell based assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
ChEMBL	Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay based Morrison titration analysis	B	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	Binding affinity for Tyk2 JH2 domain	-	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation	B	7.24	pIC50	58	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in IL-23 stimulated human Kit225 T cells by luciferase reporter gene assay	B	7.92	pIC50	12	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in IFN-alpha stimulated human Kit225 T cells by luciferase reporter gene assay	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	-	-	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay	B	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]