BAY-593074 [Ligand Id: 10348] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1354658 (BAY-593074) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | B | 7.32 | pKi | 48.3 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| ChEMBL | Displacement of [3H]BAY-38-7271 from CB1 receptor in human brain cortex membranes after 90 mins by scintillation counting | B | 7.32 | pKi | 48.3 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| GtoPdb | - | - | 7.32 | pKi | 48.3 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Displacement of [3H]BAY-38-7271 from CB1 receptor in Wistar rat brain membranes after 90 mins by scintillation counting | B | 7.26 | pKi | 55.4 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| ChEMBL | Displacement of [3H]CP55940 from rat cannabinoid CB1 receptor | B | 7.26 | pKi | 55.4 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| GtoPdb | - | - | 7.26 | pKi | 55.4 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| GtoPdb | - | - | 7.34 | pKi | 45.5 | nM | Ki | J Pharmacol Exp Ther (2004) 310: 620-32 [PMID:15140913] |
| ChEMBL | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | B | 7.34 | pKi | 45.5 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
| ChEMBL | Displacement of [3H]BAY-38-7271 from recombinant human CB2 receptor expressed in CHO cells after 90 mins by scintillation counting | B | 7.34 | pKi | 45.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| ChEMBL | Displacement of [3H]CP55940 from human cannabinoid CB2 receptor | B | 7.34 | pKi | 45.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5999-6002 [PMID:21880487] |
| GPR183/G-protein coupled receptor 183 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259470] [GtoPdb: 81] [UniProtKB: P32249] | ||||||||
| ChEMBL | GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183 | F | 5.51 | pIC50 | 3060.7 | nM | IC50 | EUbOPEN Chemogenomics Library - GPCR Dose-Respose |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
