GSK417651A [Ligand Id: 10279] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1506485 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPC3/Short transient receptor potential channel 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417348] [GtoPdb: 488] [UniProtKB: Q13507] | ||||||||
| ChEMBL | Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | B | 5.9 | pIC50 | 1260 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4979-4984 [PMID:23886683] |
| GtoPdb | Inhibition of recombinant hTRPC3-mediated, carbachol-stimulated Ca2+/Na+ influx in HEK293-MSRII cells assessed by FLIPR assay. | - | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4979-84 [PMID:23886683] |
| TRPC6/Short transient receptor potential channel 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417347] [GtoPdb: 491] [UniProtKB: Q9Y210] | ||||||||
| ChEMBL | Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4979-4984 [PMID:23886683] |
| GtoPdb | Inhibition of recombinant hTRPC6-mediated, carbachol-stimulated Ca2+/Na+ influx in HEK293-MSRII cells assessed by FLIPR assay. | - | 6.36 | pIC50 | 440 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4979-84 [PMID:23886683] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
