ChEMBL ligand: CHEMBL1615281 (4-{[(4'-Fluorophenyl)Carbamoyl]Amino}Benzenesulfonamide, NSC-213841, Slc-0111, SLC0111, U-104)
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
GtoPdb	-	-	5.29	pKi	5080	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3 [PMID:26233435]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human carbonic anhydrase 1 for 15 mins by stopped flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human recombinant CA1 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of human CA1 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	5.29	pKi	5080	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	5.29	pKi	5080	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human CA1 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	5.29	pKi	5080	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	5.29	pKi	5080	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human carbonic anhydrase 2 for 15 mins by stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human recombinant CA2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of human CA2 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	6.02	pKi	960	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	6.02	pKi	960	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CAH2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.02	pKi	960	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human CA2 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	6.02	pKi	960	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay	B	7.02	pKi	96	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.02	pKi	96	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.02	pKi	96	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.54	pKi	286	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.35	pKi	45.1	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human CA9 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	7.35	pKi	45.1	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.35	pKi	45.1	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay	B	7.35	pKi	45.1	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	7.35	pKi	45.1	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of carbonic anhydrase 9 (unknown origin)	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.35	pKi	45	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of human CA9 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Binding affinity to human CA9 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human carbonic anhydrase 9 for 15 mins by stopped flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human recombinant CA9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
GtoPdb	-	-	7.35	pKi	45	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3 [PMID:26233435]
ChEMBL	Inhibition of human CAH9 catalytic domain expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	9	pKi	1	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	5.07	pKi	8550	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	5.07	pKi	8550	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	5.07	pKi	8550	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human carbonic anhydrase 12 for 15 mins by stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of human CA12 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	8.35	pKi	4.5	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human CA12 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
GtoPdb	-	-	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3 [PMID:26233435]
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.19	pKi	6.4	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]