Src family: Introduction

Activation of Src-family kinases leads to both stimulatory and inhibitory signaling responses, with cell-specific and signaling pathway-specific outcomes and redundancy of kinase function.

Immune system:
In immune cells Src kinases are involved in many signalling pathways, including ITAM- and ITIM-domain-containing receptor signaling, integrin signaling, and responses to chemokines/chemoattractants, cytokines, innate immune stimuli and a large variety of non-immune cell specific stimuli (UV irradiation, heat, osmotic shock etc.). In many cases Src kinases signal to MAP kinase or NF-κB pathways, but they can also modulate other pathways through less well characterized mechanisms.

The primary T cell Src kinases are Lck and Fyn; the main B cell Srcs are Lyn, Fyn and Blk. Mast cells express Fyn and Lyn, with low expression of Src.

How to cite this page

To cite this family introduction, please use the following:

Src family, introduction. Last modified on 15/11/2018. Accessed on 19/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/FamilyIntroductionForward?familyId=619.