Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
« Hide
More detailed introduction
Activation of Src-family kinases leads to both stimulatory and inhibitory signaling responses, with cell-specific and signaling pathway-specific outcomes and redundancy of kinase function.
Immune system:
In immune cells Src kinases are involved in many signalling pathways, including ITAM- and ITIM-domain-containing receptor signaling, integrin signaling, and responses to chemokines/chemoattractants, cytokines, innate immune stimuli and a large variety of non-immune cell specific stimuli (UV irradiation, heat, osmotic shock etc.). In many cases Src kinases signal to MAP kinase or NF-κB pathways, but they can also modulate other pathways through less well characterized mechanisms.
The primary T cell Src kinases are Lck and Fyn; the main B cell Srcs are Lyn, Fyn and Blk. Mast cells express Fyn and Lyn, with low expression of Src.
Blk (BLK proto-oncogene, Src family tyrosine kinase)
C
Show summary »
More detailed page |
Fgr (FGR proto-oncogene, Src family tyrosine kinase)
Show summary »
More detailed page |
FRK (fyn related Src family tyrosine kinase)
C
Show summary »
More detailed page |
Fyn (FYN proto-oncogene, Src family tyrosine kinase)
C
Show summary »
More detailed page |
Hck (HCK proto-oncogene, Src family tyrosine kinase)
Show summary »
More detailed page |
Lck (LCK proto-oncogene, Src family tyrosine kinase)
Show summary »
More detailed page |
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
C
Show summary »
More detailed page |
Brk (protein tyrosine kinase 6)
Show summary »
More detailed page |
Src (SRC proto-oncogene, non-receptor tyrosine kinase)
C
Show summary »
More detailed page |
Srm (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites)
Show summary »
More detailed page |
Yes (YES proto-oncogene 1, Src family tyrosine kinase)
Show summary »
More detailed page |
Database page citation:
Src family. Accessed on 30/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=619.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.