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Cervical cancer

Disease ID:205
Name:Cervical cancer
Associated with:4 targets
Database Links
Disease Ontology: DOID:4362
OMIM: 603956


Role:  EAG mRNA expression and channel activity detected in cervical carcinoma tissue
Comments:  EAG expression and channel activity have been suggested to be important in cell proliferation. EAG considered potential cervical cancer tumour marker / membrane therapeutic target. Inhibition by siRNA showed suppression of tumour cell proliferation and treatment with antibodies (in vitro and in vivo) has shown similar results. However ion permeation blocking mutations failed to abolish xenograft tumour formation.
References:  1-4
fibroblast growth factor receptor 3


No ligand related data available for Cervical cancer


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1. Downie BR, Sánchez A, Knötgen H, Contreras-Jurado C, Gymnopoulos M, Weber C, Stühmer W, Pardo LA. (2008) Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem, 283 (52): 36234-40. [PMID:18927085]

2. Farias LM, Ocaña DB, Díaz L, Larrea F, Avila-Chávez E, Cadena A, Hinojosa LM, Lara G, Villanueva LA, Vargas C, Hernández-Gallegos E, Camacho-Arroyo I, Dueñas-González A, Pérez-Cárdenas E, Pardo LA, Morales A, Taja-Chayeb L, Escamilla J, Sánchez-Peña C, Camacho J. (2004) Ether a go-go potassium channels as human cervical cancer markers. Cancer Res, 64 (19): 6996-7001. [PMID:15466192]

3. Gómez-Varela D, Zwick-Wallasch E, Knötgen H, Sánchez A, Hettmann T, Ossipov D, Weseloh R, Contreras-Jurado C, Rothe M, Stühmer W et al.. (2007) Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res, 67 (15): 7343-9. [PMID:17671204]

4. Weber C, Mello de Queiroz F, Downie BR, Suckow A, Stühmer W, Pardo LA. (2006) Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem, 281 (19): 13030-7. [PMID:16537547]