Contents:
| Quaternary Structure: Complexes |
| AMY3 receptor |
| AM2 receptor |
Gene and Protein Information  |
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| Receptor activity modifying protein | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | References |
| Human | 1 | 148 | 7p13-p12 | RAMP3 | receptor activity modifying protein 3 | 1,3 |
| Mouse | 1 | 147 | 11 A1 | Ramp3 | receptor (calcitonin) activity modifying protein 3 | 1 |
| Rat | 1 | 147 | 14q21 | Ramp3 | receptor activity modifying protein 3 | |
| Previous and Unofficial Names |
| receptor activity modifying protein 3 |
| receptor (G protein-coupled) activity modifying protein 3 |
| Database Links |
|
| Alphafold | O60896 (Hs), Q9WUP1 (Mm), Q9JJ73 (Rn) |
| ChEMBL Target | CHEMBL2111190 (Hs), CHEMBL2111191 (Hs), CHEMBL2109235 (Rn) |
| DrugBank Target | O60896 (Hs) |
| Ensembl Gene | ENSG00000122679 (Hs), ENSMUSG00000041046 (Mm), ENSRNOG00000053766 (Rn) |
| Entrez Gene | 10268 (Hs), 56089 (Mm), 56820 (Rn) |
| Human Protein Atlas | ENSG00000122679 (Hs) |
| KEGG Gene | hsa:10268 (Hs), mmu:56089 (Mm), rno:56820 (Rn) |
| OMIM | 605155 (Hs) |
| Pharos | O60896 (Hs) |
| RefSeq Nucleotide | NM_005856 (Hs), NM_019511 (Mm), NM_020100 (Rn) |
| RefSeq Protein | NP_005847 (Hs), NP_062384 (Mm), NP_064485 (Rn) |
| UniProtKB | O60896 (Hs), Q9WUP1 (Mm), Q9JJ73 (Rn) |
| Wikipedia | RAMP3 (Hs) |
| Protein Comments |
|
In situ hybridisation studies of the rat brain show RAMP3 mRNA to be located predominantly in the thalamus [4]. Immunochemistry shows RAMP3 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5]. Northern blotting shows mouse RAMP3 mRNA to be located predominantly in the brain, as well as weaker expression in the heart and kidney [2]. |
References
1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet, 90 (1-2): 115-8. [PMID:11060459]
2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]
3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]
4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]
5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab, 22 (5): 620-9. [PMID:11973435]
How to cite this page
RAMP3. Last modified on 27/04/2006. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=53.
