GKT136901 [Ligand Id: 9935] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1276946
  • cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
ChEMBL Inhibition of human NOX2 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 5.82 pKi 1530 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
GtoPdb Cell free assay of ROS production by NOX2 membranes. - 5.82 pKi 1530 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
NADPH oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287628] [GtoPdb: 3001] [UniProtKB: Q9Y5S8]
ChEMBL Inhibition of human NOX1 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
GtoPdb Cell free assay of ROS production by NOX1 membranes. - 6.8 pKi 160 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
NADPH oxidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250375] [GtoPdb: 3004] [UniProtKB: Q9NPH5]
GtoPdb Cell free assay of ROS production by NOX4 membranes. - 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
ChEMBL Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase by in vitro enzymatic assay in presence of xanthine B 4.52 pKi >30000 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]