flumbatinib [Ligand Id: 9913] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3545413 (Flumatinib, Flumbatinib, Hhgv-678, HH-GV678) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of c-Kit (unknown origin) | B | 6.18 | pIC50 | 665.5 | nM | IC50 | Eur J Med Chem (2022) 238: 114442-114442 [PMID:35551036] |
| GtoPdb | - | - | 6.18 | pIC50 | 666 | nM | IC50 | Leukemia (2010) 24: 1807-9 [PMID:20703259] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| GtoPdb | - | - | 6.51 | pIC50 | 307 | nM | IC50 | Leukemia (2010) 24: 1807-9 [PMID:20703259] |
| ChEMBL | Inhibition of PDGFRbeta (unknown origin) | B | 6.51 | pIC50 | 307.6 | nM | IC50 | Eur J Med Chem (2022) 238: 114442-114442 [PMID:35551036] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| GtoPdb | - | - | 8.92 | pIC50 | 1.2 | nM | IC50 | Leukemia (2010) 24: 1807-9 [PMID:20703259] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
