levosalbutamol [Ligand Id: 9816] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1002 (Albuterol (r)-form, ASF-1096, Levalbuterol, Levosalbutamol, R-salbutamol, Xopenex) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells | B | 5.25 | pKi | 5623.41 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells | B | 5.25 | pKi | 5623 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM phenylboronic acid | B | 5.33 | pKi | 4677.35 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM phenylboronic acid | B | 5.33 | pKi | 4677 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM boric acid | B | 5.42 | pKi | 3802 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM boric acid | B | 5.42 | pKi | 3801.89 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid | F | 6.34 | pEC50 | 457.09 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid | F | 6.34 | pEC50 | 457 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid | F | 6.56 | pEC50 | 275.42 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid | F | 6.56 | pEC50 | 275 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting | F | 6.84 | pEC50 | 145 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting | F | 6.84 | pEC50 | 144.54 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 4.7 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| GtoPdb | - | - | 6.2 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
