butoxamine [Ligand Id: 9809] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL289093 (Butaxamina, Butaxamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria | F | 4.35 | pKd | 44668.36 | nM | Kd | J Med Chem (1985) 28: 153-160 [PMID:2857200] |
| ChEMBL | Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria | F | 4.35 | pKd | 44668.36 | nM | Kd | J Med Chem (1987) 30: 616-622 [PMID:2882026] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal strips | F | 6.89 | pKd | 128.82 | nM | Kd | J Med Chem (1985) 28: 153-160 [PMID:2857200] |
| ChEMBL | Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig trachea | F | 6.89 | pKd | 128.82 | nM | Kd | J Med Chem (1987) 30: 616-622 [PMID:2882026] |
| β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| β2-adrenoceptor in Rat [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
| GtoPdb | - | - | 6.51 | pKi | 309 | nM | Ki |
Jpn J Pharmacol (1990) 52: 195-200 [PMID:1968985]; Br J Pharmacol (1983) 79: 429-39 [PMID:6140042] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
