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Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase

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Target id: 2980

Nomenclature: Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Abbreviated Name: PfDXR

Family: Non-mevalonate pathway enzymes

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 488 DXR 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Previous and Unofficial Names Click here for help
DXR | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | DOXR | IspC | DOXP reductoisomerase | DXP reductoisomerase
Database Links Click here for help
ChEMBL Target
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
fosmidomycin Small molecule or natural product Ligand has a PDB structure PfDd2 Parasite growth inhibition assay - - 6.5 pIC50 1
pIC50 6.5 (IC50 2.9x10-7 M) [3H]-hypoxanthine incorporation assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
fosmidomycin Small molecule or natural product Ligand has a PDB structure PfHB3 Parasite growth inhibition assay - - 6.5 pIC50 1
pIC50 6.5 (IC50 3.5x10-7 M) [3H]-hypoxanthine incorporation assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
fosmidomycin Small molecule or natural product Ligand has a PDB structure PfA2 Parasite growth inhibition assay - - 6.4 pIC50 1
pIC50 6.4 (IC50 3.7x10-7 M) [3H]-hypoxanthine incorporation assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
The non-mevalonate (MEP) pathway of isoprenoid precursor biosynthesis is utilized by bacteria, plants and apicomplexan protozoa but is not present in mammals (complete pathway for P. falciparum is available at www.wikipathways.org).
1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme in the pathway, is of interest as a therapeutic target for antimalarial drug development [1].

References

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1. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Türbachova I, Eberl M, Zeidler J, Lichtenthaler HK et al.. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science, 285 (5433): 1573-6. [PMID:10477522]

How to cite this page

Non-mevalonate pathway enzymes: Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Last modified on 02/02/2021. Accessed on 19/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2980.