Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	488		DXR	1-deoxy-D-xylulose 5-phosphate reductoisomerase

Previous and Unofficial Names

DXR | Pf3D7_14_v3:2,750,164..2,752,514(+) | DOXR | IspC | DOXP reductoisomerase | DXP reductoisomerase | DXPR | PF14_0641

Database Links
Alphafold	Q8IKG4 (Pf3D7)
ChEMBL Target	CHEMBL4295619 (Pf3D7)
PlasmoDB	PF3D7_1467300 (Pf3D7)
UniProtKB	Q8IKG4 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference fosmidomycin PfDd2 Plasmodium falciparum Dd2 P. falciparum strain Dd2 (PfDd2) is a clone derived from PfW2, following continuous culture in mefloquine. PfW2 was cloned from the Indochina III/CDC isolate, originally derived from a Laotian patient who failed chloroquine therapy. PfDd2 can be obtained from the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be resistant to chloroquine, pyrimethamine and mefloquine. ✖ Parasite growth inhibition assay - - 6.5 pIC50 1 ⤷ pIC50 6.5 (IC50 2.9x10-7 M) [3H]-hypoxanthine incorporation assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont) fosmidomycin PfHB3 Plasmodium falciparum HB3 P. falciparum strain HB3 (PfHB3) was cloned from the Honduras I/CDC strain, originally isolated from a patient in Choluteca, Honduras, during an outbreak of urban malaria in January 1980. PfHB3 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be chloroquine sensitive. ✖ Parasite growth inhibition assay - - 6.5 pIC50 1 ⤷ pIC50 6.5 (IC50 3.5x10-7 M) [3H]-hypoxanthine incorporation assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont) fosmidomycin PfA2 Plasmodium falciparum A2 P. falciparum A2 (PfA2) originates from The Gambia (PMID:10477522). ✖ Parasite growth inhibition assay - - 6.4 pIC50 1 ⤷ pIC50 6.4 (IC50 3.7x10-7 M) [3H]-hypoxanthine incorporation assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

The non-mevalonate (MEP) pathway of isoprenoid precursor biosynthesis is utilized by bacteria, plants and apicomplexan protozoa but is not present in mammals (complete pathway for P. falciparum is available at www.wikipathways.org). 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme in the pathway, is of interest as a therapeutic target for antimalarial drug development [1].