CP-226269 [Ligand Id: 973] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL77395 (CP-226269) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity towards human Dopamine receptor D2 | B | 6.92 | pKi | 120 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay | B | 6.28 | pEC50 | 527 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay | B | 7.26 | pEC50 | 55 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity towards human Dopamine receptor D3 | B | 6.25 | pKi | 560 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity towards human D4.4 receptor | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | Effective concentration against human Dopamine receptor D4 | B | 7.49 | pEC50 | 32 | nM | EC50 | J Med Chem (2004) 47: 2348-2355 [PMID:15084133] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D4 using FLIPR assay | B | 7.49 | pEC50 | 32 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| GtoPdb | - | - | 9.4 | pKi | - | - | - | Mol Pharmacol (2004) 66: 1491-9 [PMID:15448188] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay | B | 7.44 | pEC50 | 36 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay | B | 7.66 | pEC50 | 22 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity towards human Opioid receptor kappa 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1A receptor | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
