(+)-SCH-23390 [Ligand Id: 956] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL63321 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1 | B | 6.72 | pKi | 192 | nM | Ki | J Med Chem (1992) 35: 502-507 [PMID:1531365] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| GtoPdb | - | - | 5.3 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582] |
| ChEMBL | Ability to partially antagonise [3H]-SCH- 23388 binding to the Dopamine receptor D2 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1988) 31: 2069-2071 [PMID:3263503] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
