ChEMBL ligand: CHEMBL54661 (Flupenthixol, Flupentixol, LC 44, LC-44, N-7009)
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728] D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
K2P2.1/Potassium channel subfamily K member 2 in Human [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] There should be some charts here, you may need to enable JavaScript!
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb	Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.	-	8.4	pKi	-	-	-	Nature (1991) 350: 614-9 [PMID:1826762]; J Biol Chem (1994) 269: 27925-31 [PMID:7525564]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2003) 13: 4015-4017 [PMID:14592497]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	5.81	pIC50	1547	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
K2P2.1/Potassium channel subfamily K member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069]
ChEMBL	Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currents	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2016) 59: 5149-5157 [PMID:26588045]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	The compound was tested for affinity towards sigma-3 receptor	B	8.65	pIC50	2.24	nM	IC50	J Med Chem (1994) 37: 4109-4117 [PMID:7990111]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	B	4.05	pIC50	89500	nM	IC50	J Med Chem (2008) 51: 5932-5942 [PMID:18788725]
ChEMBL	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	B	4.05	pIC50	89500	nM	IC50	J Med Chem (2008) 51: 5932-5942 [PMID:18788725]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3]
ChEMBL	Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay	B	5.15	pIC50	7000	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb	-	-	8.82	pKi	1.5	nM	Ki	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb	-	-	8.96	pKi	1.1	nM	Ki	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
GtoPdb	-	-	8.1	pKi	-	-	-	Nature (1991) 350: 614-9 [PMID:1826762]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]